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LUX-Lung 8: Afatinib Tops Erlotinib in Squamous NSCLC
Data from the LUX-Lung 8 trial showed afatinib outperformed erlotinib with regard to both progression-free and overall survival in squamous cell lung cancer.
AZD9291 Shows Promise in EGFR-Mutated NSCLC
A new agent, AZD9291, showed promising clinical activity and progression-free survival in a study of patients with advanced stage, EGFR mutation-positive NSCLC.
Pembrolizumab Effective in Metastatic Head and Neck Cancer
Pembrolizumab demonstrated a 24.8% overall response rate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
Elective Dissection of Lymph Nodes Improves Survival in Early Oral Cancer
Elective neck lymph node surgery for patients with early oral cancer reduces the risk of cancer recurrence and improves survival.
Immediate ADT Improved Survival in Prostate Cancer With Rising PSA
Immediate ADT improved overall survival compared with delayed ADT in prostate cancer patients with a rising prostate-specific antigen level.
New Subtype of mCRPC Refractory to Androgen Receptor Inhibition ID'd
Researchers have identified a new histologic subset of metastatic castration-resistant prostate cancer that is refractory to androgen receptor inhibition.
Reduction in Late Mortality Improves Childhood Cancer Survival
An analysis of more than 34,000 5-year survivors of childhood cancer treated over 3 decades finds that modern treatments have reduced long-term mortality rates.
Durable Responses Seen With Pembrolizumab in Melanoma Patients
Data from the KEYNOTE-001 study showed that the anti–PD-1 antibody pembrolizumab produces durable responses in metastatic melanoma patients.
Examining BRAF-Inhibitor Resistance Offers Few Clues in Melanoma Treatment
Due to the genetic heterogeneity observed in tumors of melanoma patients who developed resistance to BRAF inhibitors, assessing mechanisms of resistance has minimal potential to inform further treatment decisions.
Higher Vitamin D Levels Linked to Improved Colorectal Cancer Survival
Increased levels of vitamin D were associated with improved overall survival rates in metastatic colorectal cancer patients treated as part of CALGB/SWOG 80405.
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