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Alemtuzumab Produces Durable Responses in CLL

Alemtuzumab Produces Durable Responses in CLL

ORLANDO—Alemtuzumab (Campath-1H), a humanized monoclonal antibody that
binds to CD52, produced a response rate of 29% (including 7% complete
responses) in heavily pretreated patients with CD52-expressing hematologic
malignancies.

In a poster presentation at the 43rd Annual Meeting of the American
Society of Hematology (abstract 1541), Alessandra Ferrajoli, MD, described
this finding from a phase II trial of alemtuzumab in 68 patients. Dr.
Ferrajoli is assistant professor in the Department of Leukemia, M.D.
Anderson Cancer Center.

Dr. Ferrajoli said that the main study objective was to determine the
efficacy of alemtuzumab in patients with hematologic malignancies expressing
CD52 who have failed conventional treatment or whose predicted response to
standard therapy was less than 20%.

The investigators treated 41 patients who had refractory B-cell chronic
lymphocytic leukemia (B-CLL), 1 who had T-CLL, 3 who had B-cell
prolymphocytic leukemia (B-PLL), 9 with T-PLL, 6 with cutaneous T-cell
lymphoma, 1 with hairy cell leukemia, 3 with mantle cell lymphoma, 2 with
T-cell large granular lymphocytic leukemia (T-LGL), and 2 with peripheral
T-cell lymphoma. The median age was 60 years; 53 patients were male and 15
female; the median number of prior treatments was three.

Alemtuzumab was given IV at 3 mg on day 1, 10 mg on day 2, 30 mg on day
3, and then 30 mg three times a week for 11 additional doses. All patients
received prophylactic trimethoprim-sulfamethoxazole and valacyclovir
(Valtrex).

Response Rate

The overall response rate was 29%, including complete response (CR) in
five patients (7%). This included two with B-CLL and three with T-PLL. The
median duration of CR was 12 months.

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