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Antisense Drug Against BCL-2 Effective in Animal Cancer Models

Antisense Drug Against BCL-2 Effective in Animal Cancer Models

SAN DIEGO--Genta Incorporated's antisense oligonucleotide targeted against the BCL-2 gene has proved effective against drug-resistant cancers in certain animal models of follicular lymphoma and colon cancer, the company said.

The BCL-2 gene is overexpressed in many tumors, preventing normal apoptosis and inducing drug resistance. A phase I/II trial in drug-resistant follicular lymphoma is scheduled to begin at The Royal Marsden Hospital, London, by mid-year.

 
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