BETHESDA, Md--A new NCI study will evaluate three techniques to manage
atypical squamous cells of undetermined significance that show up on Pap
smears, including their cost effectiveness and acceptability to women.
The trial will evaluate colposcopy; repeating Pap smears every six months;
and human papillomavirus (HPV) testing as a means to differentiate between
abnormalities that need immediate colposcopy and those that can best be
followed with repeat Pap tests at six-month intervals.
The study enrollment of 7,200 women with mild Pap test abnormalities
should be completed next year. Participants will be followed for three
years. The study centers are the University of Alabama at Birmingham, University
of Oklahoma, Magee-Womens Hospital, and the University of Washington.