NEW CANAAN, ConnecticutThe Multiple Myeloma Research Foundation
(MMRF) has announced the recipients of the first MMRF Collaborative Program
Grant, which is funding $1.5 million over 3 years to three centers of
excellence in myeloma research: Dana-Farber Cancer Institute, Mayo Clinic, and
H. Lee Moffitt Cancer Center.
The winning grant, entitled "Development of Novel Target-based
Therapies for Multiple Myeloma," encompasses three inter-related projects
and one unifying core. The focus will be to identify new therapies
and rapidly move promising leads from the bench to the bedside for evaluation
in clinical trials at all three institutions.
Project 1 will characterize the cell pathways involved in myeloma cell
growth, survival, and migration in the bone marrow environment to identify
novel molecular targets for therapy. Centered at Dana-Farber, this project is
headed by Kenneth C. Anderson, MD, who will also serve as the principal
investigator for the entire program. Project 2, centered at the Moffitt Cancer
Center and headed by William Dalton, MD, will investigate how myeloma cells
become resistant to therapy, with the goal of designing strategies to prevent
or overcome drug resistance.
Project 3 at the Mayo Clinic will evaluate the role of angiogenesis in
disease progression. It is led by Robert Kyle, MD, Vincent Rajkumar, MD, and
Stephen Russell, MD, PhD. The fourth component is the central core laboratory
that will perform gene analysis for the entire program. It is headed by Nikhil
C. Munshi, MD, of Dana-Farber.