Color Atlas of Clinical Hematology, Third Edition

Color Atlas of Clinical Hematology, Third Edition

The third edition of the Color Atlas of Clinical
, authored by Drs. A. Victor Hoffbrand and John E. Pettit,
contains 19 chapters covering the entire spectrum of hematology, including
normal hematopoiesis, benign and malignant hematologic diseases,
nonhematopoietic diseases, stem cell transplantation, coagulation disorders, and
blood transfusion. During the course of their careers as hematologists, the
authors have accumulated a vast collection of clinical, microscopic, and
radiographic illustrations of hematologic diseases, many of which are displayed
herein. This collection is supplemented by photos contributed by their
colleagues and a variety of other diagrams and tables, resulting in a
comprehensive and richly illustrated atlas of both common and rare hematologic
disorders. The fact that the authors integrate clinical, microscopic, and
radiologic images makes the book especially valuable.

More than a picture book, each section of the atlas contains text with
up-to-date information about the clinical and pathologic characteristics of each
disorder. The discussions are necessarily brief but provide the most pertinent
information and add tremendously to the value of this atlas as a reference and
teaching tool.

The first chapter is devoted to normal hematopoiesis, with extensive
illustrations of blood cell growth and differentiation. It also discusses the
morphology and function of normal blood, bone marrow, and lymphoid tissue as
well as immunoglobulin production and immune response.

Chapters 2 through 6 focus on anemia, both congenital and acquired. Among the
many illustrations in these chapters are images of koilonychia and angular
cheilosis in a patient with severe iron deficiency, blood and bone marrow
morphology in congenital dyserythropoietic anemia, and illustrations of a wide
variety of genetic disorders of hemoglobin, including a fetus with alpha-thalassemia
hydrops fetalis. The discussions are informative and enhance the educational
value of this section.

Chapter 7 covers benign disorders of leukocytes, including several congenital
abnormalities such as the May Hegglin anomaly, benign leukocytoses (eg, toxic
neutrophilia and infectious mononucleosis), cytopenias (eg, Kostman’s
syndrome), histiocytic proliferations, and immunodeficiency syndromes.

The chapters on acute leukemia, myelodysplastic syndrome, and chronic
myeloproliferative disorders (8, 9, and 13, respectively) discuss not only the
morphologic aspects but also the immunophenotypic and genetic findings, when
appropriate. The French, American, and British (FAB) classification is used for
acute leukemia, although the proposed World Health Organization (WHO)
classification for these disorders is included as an appendix at the end of the

The sections on chronic lymphoid leukemias and malignant lymphoma (chapters
10 and 11) include the Working Formulation, the Revised European-American
Classification of Lymphoid Neoplasms (REAL classification), and the proposed WHO
classification of B- and T-cell neoplasms. By integrating the proposed WHO
classification and relating it to other recently utilized classification
schemes, the authors have made the chapter more relevant and timely.


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