This clinically oriented text focuses on the diagnosis and management
of endometrial adenocarcinoma and endometrial hyperplasia. Due to its
clinical orientation, the book does not include information on the
molecular basis of endometrial cancer.
At 288 pages, the book is relatively short but is strengthened by the
liberal inclusion of tables, figures, histopathology
photomicrographs, and other useful photographs. Although the book is
generally well written in a fairly uniform fashion, there are areas
of unnecessary repetition.
The first chapter centers on the epidemiology of endometrial
carcinoma. Although concise, this chapter adds little new information
to other published chapters on the topic. Few of the references were
published later than 1994. Also, the chapter provides no discussion
on inherited cancer syndromes that place a woman at higher risk of
The second chapter focuses on methods of early diagnosis and
potential methods of screening women for endometrial cancer. It
contains 42 excellent illustrations of endometrial pathology noted at hysteroscopy.
The third chapter reviews endocrine aspects of the uterus as they
relate to endometrial cancer. It starts out with a nice overview of
endometrial anatomy and physiology. There is very little discussion
of the effects of tamoxifen (Nolvadex) on the uterus, however, and no
mention of the effects of raloxifene (Evista). Another blatant
omission is any discussion of the hormonal therapy of advanced
endometrial adenocarcinoma. Also missing is advice on how to manage
young women with grade 1 endometrial adenocarcinoma who wish to
Chapters 4 and 5 deal with the pathology of endometrial hyperplasia
and endometrial adenocarcinoma, respectively. The author presents a
nice discussion of biological prognostic indicators. The chapter
contains over 40 excellent photomicrographs but no gross
Chapter 6 describes treatment modalities for endometrial hyperplasia.
The authors suggest the use of endometrial ablation as an alternative
treatment for medically resistant forms of endometrial hyperplasia
(without cytologic atypia), and devote a significant portion of the
chapter to a discussion of various methods of performing ablation.
This discussion seems out of place since most authorities agree that
endometrial cancer and its precursors should not be treated with
Chapters 7 and 8, which cover staging and prognostic factors in
endometrial carcinoma, respectively, could have been combined into
one chapter. Overall, these discussions are thorough and very good.
Chapters 9 and 10 focus on the surgical management of endometrial
cancer, with a nice discussion of the use of laparoscopy.
Chapter 11, which explores the role of radiation therapy in
endometrial cancer, is an excellent overview on the subject. The
authors include many photographs or figures of equipment and
radiation techniques used in the treatment of patients with uterine cancer.
The final chapter is a well-written review of the role of
chemotherapy in patients with advanced endometrial cancer. It
includes data on the efficacy of both single-agent and combination
Overall, Endometrial Carcinoma and Precursors is a very good text
that presents a focused, relatively concise discussion of endometrial
carcinoma. It should be a useful aid to practitioners who manage
women with endometrial cancer.