Topics:

Final Word on Diet-Breast Cancer Link Must Come From Clinical Trials: WHI

Final Word on Diet-Breast Cancer Link Must Come From Clinical Trials: WHI

BETHESDA, Md--Concerned that a New England Journal of Medicine
article reporting no link between fat intake and breast cancer
might deter women from joining the diet-cancer segment of the
NIH-sponsored Women's Health Initiative (WHI), its top leaders
took an unusual step.

They issued a press statement that challenges, not the article's
findings, but the notion that the question of whether dietary
fat contributes to the development of breast cancer can be answered
outside of a randomized clinical trial.

"Numerous other studies . . . support such a link,"
the statement said. "The WHI trial is designed to answer
confidently this and other important questions related to women's
health."

The article, which appeared in the February 8, 1996, issue of
the Journal and garnered extensive media attention, detailed a
reanalysis of seven cohort studies that had investigated the link
between fat and breast cancer. The studies involved a total of
337,819 women.

"We found no evidence of a positive association between total
dietary fat intake and the risk of breast cancer," said lead
author David J. Hunter of the Harvard School of Public Health.
"There was no reduction in risk even among women whose energy
intake from fat was less than 20% of total energy intake."

The article noted, and the WHI statement emphasized, that other
types of studies have reached contrary conclusions. These include
epidemiologic studies, comparisons of women living in one country
with those from that country who have migrated to another and
changed their diet, case-control studies, and animal feeding trials.

This leads to the possibility that the new findings might result
from some defect within cohort studies themselves, the WHI statement
said. In cohort studies, the amount of fat is estimated prior
to the development of a breast tumor; in case-control studies,
the estimate comes after the cancer appears. Cohort studies generally
get the nod over case-control studies as the more reliable. However,
"neither of these types of studies is as reliable as a clinical
trial," the WHI said.

Pages

 
Loading comments...
Please Wait 20 seconds or click here to close