BETHESDA, MdThe National Cancer Institute-sponsored Early
Detection Research Network has issued 13 grants totaling $18 million
to complete its first year of funding. Last fall, NCI awarded $8
million to set up the networks initial operations18
biomarker development laboratories. The new grants will finance the
establishment of the programs other three components: clinical
and epidemiologic centers, biomarker validation laboratories, and a
data management and coordinating center.
The aim of the network is to unite dozens of research institutions in
efforts to search for and evaluate new ways to test for early cancer
and for cancer risk.
Advances in cancer genetics, protein analysis, and other fields
offer potential new biomarkers that one day may reduce the burden of
cancer, said Sudhir Srivastava, PhD, MPH, chief of the cancer
biomarkers research group in NCIs Division of Cancer
Prevention. But before they can move from the lab to the
clinic, these biomarkers need to be tested systematically. Pooling
resources and expertise is vital to this kind of validation.
The new grants will finance:
Nine clinical and epidemiologic centers that will provide the network
with blood, tissue, and other biological samples, as well as medical
information on families with a history of cancer, for use in a
large-scale evaluation of cancer biomarkers.
Three biomarker validation laboratories, which will standardize
biomarker tests, assure their reproducibility, and ready the best
tests for clinical trials.
A data management and coordination center to develop standards for
data reporting and research new statistical methods for analyzing