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HIV Has Become a Specialty Disease, But One Open to the Well-Informed Generalist

HIV Has Become a Specialty Disease, But One Open to the Well-Informed Generalist

PHILADELPHIA--Personal devotion to keeping abreast of the complexity of HIV therapy identifies the "specialist," whether trained in infectious disease or as a generalist, John J. Bartlett, MD, said at the American College of Physicians annual meeting.

"In the last year and a half, the velocity of new developments in HIV disease has become so compelling, so overwhelming, that it has transformed the field into a specialist disease," said Dr. Bartlett, chief of infectious diseases, Johns Hopkins University. "Today, the complexity of care right from the beginning is such that you really have to follow the disease in order to manage HIV patients."

Know the Drugs

There are now 10 antiretroviral drugs available in the United States, Dr. Bartlett pointed out. "To do HIV care, you've got to know about all 10 because you're going to have to use all 10. That means you've got to know their doses, side effects, interactions, cross-resistance, the order in which they can be given, and their synergy and antagonism with other drugs." But, he said, that doesn't necessarily mean that the physician must have trained in an infectious disease specialty. "You just have to be able to keep up with what's going on in the field and follow an essential mass of patients. In our clinic, we define an essential mass as one unit, which is 50 patients."

50/50 Split

Speaking at the same session, Douglas S. Paauw, MD, echoed Dr. Bartlett's statements. "The things I learned about HIV in my residency 10 years ago are completely out of date now," he said. "If I had stopped there, I would be unable to continue following HIV patients." He believes, however, that there is an important role for the generalist in caring for patients with HIV.

In Seattle, where Dr. Paauw is associate professor of medicine, division of internal medicine, University of Washington School of Medicine, HIV practice is split about fifty-fifty among physicians trained in infectious disease and those trained in general medicine. "We also have a few well-trained family practitioners who have taken up HIV care. So it's not based on training in medical school or residency as much as on the desire to keep up in the field."

The generalist also has an important role in curbing the spread of HIV in the sense of recognizing it early, Dr. Paauw commented.

"Patients with HIV infection can present in many different ways," he said. "They usually come to their primary care physician. They don't always give a risk factor history right up front, so being able to pick up on some of the early clues of HIV is very important."

With the advent of so many new antiretroviral drugs, he added, one of the key parts of being an HIV care provider "is being an incredible pharmacist."

Dr. Paauw outlined two instances in which the generalist who treats HIV patients should probably consider referral to a specialist.

One is the case of the patient who has antiretroviral failure, that is, has failed both a standard regimen and a salvage regimen. "I think that's when it would make sense to refer the patient to a physician who has treated 50 to 100 patients in a panel or is involved in ongoing studies," he said.

Referrals may also be necessary in patients who have persistent symptoms despite a standard workup.

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