BUFFALO, NY--Researchers at Roswell Park Cancer Institute are recruiting
patients for enrollment in 19 different protocols testing unique treatments
for HIV-infected individuals. The goal of these protocols is to preserve
or enhance the fragile immune system while treating and preventing malignancy.
"We are involved in several new protocols that we hope will improve
the outcome for HIV-infected patients," said Zale P. Bernstein, MD,
director of The Center for HIV-Related Malignancies at Roswell Park. "Some
are new, such as photodynamic therapy. We are also developing regimens
that allow for prolonged restitution of the immune system in this population
of patients using interleukin-2 (IL-2)."
Photodynamic therapy (PDT) was pioneered at Roswell Park, Dr. Bernstein
said in his presentation at the Roswell Park-sponsored conference "HIV,
Cancer & the Family." PDT combines tissue-penetrating red laser
light and a non-toxic, light-sensitive chemical (the photosensitizer) that,
when injected into the body, remains in tumor tissue.
Efficiently delivered through fiberop-tics, the red light strikes the
sensitized cancer cells, and a tumor-destructive oxygen is released. Protocols
at the Institute are studying the efficacy of this treatment in Kaposi's
sarcoma, and early results show decreasing lesions with excellent palliative
and cosmetic results.
A new study involving GM-CSF is in the early phases. The daily, subcutaneous
injection of GM-CSF appears to abrogate the immune suppression engendered
by HIV. "We believe that the daily use of this substance will prevent
the development of opportunistic infection and malignancy in this group
of patients," Dr. Bernstein commented.
Research suggests that utilizing anti-neoplasm and antiretrovirus agents
in combination will destroy and prevent regeneration of HIV. A current
protocol combines hydroxyurea (Hydrea), a DNA inhibitor, and didanosine
(ddI, Videx), a reverse transcriptase inhibitor. Together they act synergistically
and appear to be well tolerated, he said.
Phase III trials of IL-2 are examining the effects of low daily maintenance
doses, rather than the large ones tested in early studies. "This IL-2
treatment appears successful; in over 40 months we have had no opportunistic
infections," Dr. Bernstein said.
Physicians interested in enrolling patients in any of these studies
may contact The Center for HIV-Related Malignancies at 1-800-685-6825,