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INTORACT trial of Torisel/Avastin in RCC is initiated

INTORACT trial of Torisel/Avastin in RCC is initiated

COLLEGEVILLE, Pennsylvania—Wyeth Pharmaceuticals has initiated the INTORACT (Investigation of Torisel and Avastin Combination Therapy) trial, a worldwide randomized open-label phase IIIb study comparing temsirolimus (Torisel) plus bevacizumab (Avastin) vs bevacizumab plus interferon-alfa for the first-line treatment of patients with advanced renal cell carcinoma. Wyeth Research is conducting the study with the support and assistance of Roche and Genentech. The primary endpoint is progression-free survival.

“We hope to learn whether a regimen that combines the angiogenesis inhibition of bevacizumab with the mTOR inhibition of temsirolimus may provide further evidence of clinical utility in advanced RCC,” said Brian Rini, MD, of the Cleveland Clinic Taussig Cancer Institute, and co-principal investigator of INTORACT.

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