OSAKA, JapanInduction with irinotecan (Camptosar) and cisplatin
(Platinol) followed by thoracic radiation combined with weekly
irinotecan in patients with unresectable nonsmall-cell lung
cancer (NSCLC) seems to be a feasible regimen in a cooperative group
setting, according to the preliminary results of a phase II study
presented in an ASCO abstract.
[A phase II study of induction chemotherapy with irinotecan and
cisplatin followed by thoracic radiation combined with weekly
irinotecan in patients with unresectable stage III NSCLC.
Yamamoto N et al: Proc Am Soc Clin Oncol (abstract
Irinotecan may be a promising radiation sensitizer for locally
advanced NSCLC, according to the Japanese research team. The overall
response rate was 63% (5.9% had a complete response, and 57.4% a
partial response). The estimated 1-year survival was 71.7%.
From February 1998 to January 1999, 68 patients were enrolled.
Eligible patients had unresectable stage III NSCLC, performance
status (PS) 0 or 1, and no prior therapy. There were 52 males and 16
females enrolled. Median age was 63 years. Twenty-two patients were
PS 0 and 46 were PS 1. Within the group, 28 patients had stage IIIA
cancer and 46 had stage IIIB cancer.
Patients received two cycles of irinotecan plus cisplatin as
induction chemotherapy followed by weekly irinotecan with concomitant
thoracic radiation, according to the following regimen: cisplatin 80
mg/m² on days 1 and 29, and irinotecan 60 mg/m² on days 1,
8, 15, 29, 36, and 43. Irinotecan 30 mg/m² on days 57, 64, 71,
78, 85, and 92. Thoracic radiation was initiated on day 57 at 2 Gy/d
(total of 60 Gy).
Grade 3-4 toxicities during induction chemotherapy were primarily
neutropenia (41%/31%). Grade 3-4 toxicities during concomittent
irinotecan and thoracic radiation consisted of neutropenia (10%/6%);
esophagitis (4%/0%); and hypoxia (4%/2%). There were no
The next step is to look at those in earlier stage
disease, said Dr. Alan Sandler, Vanderbilt University, in an ONI
interview. The investigators showed that its feasible and
may prove to be an interesting combination. Obviously further study
is warranted, particularly in randomized trials.