WASHINGTON--Breast cancer mortality continues to drop among white
women in the United States, Canada, and Great Britain, and, for the
first time, it has dropped in black American women, NCI Director
Richard Klausner said in his delivery of the 6th Annual Jo Oberstar
Memorial Lecture at the George Washington University School of Medicine.
Although the reasons for the drop are not certain, Dr. Klausner
believes that "the most profound component is adjuvant therapy,
with early detection also playing a role."
New statistics released by the Centers for Disease Control and
Prevention in early October show the incidence of breast cancer
rising 34% among white women and 47% among black women in the United
States between 1973 and 1992. "Virtually all of the increased
incidence over the last 15 years has been the diagnosis of early,
localized breast cancer," Dr. Klausner said.
During most of this same period, breast cancer mortality remained
flat and then began decreasing in white women in 1989. "In the
United States, Canada, and Great Britain, suddenly there was a
change," he said. "It's been decreasing every year, and the
latest data suggest that this trend is continuing at the same slope."
In the United States, the overall decline for white women has been
6%, but this varies among various age groups. "There is a 13% to
14% drop in mortality in the youngest group of women [those under age
40], and about 10% at age 40 to 49," he noted. The decrease
began first in younger women and then appeared in older age groups.
"For the first time last year, we saw the beginning of this same
pattern for African-American women," Dr. Klausner said. "We
see for the first time breast cancer deaths being flat or dropping
for all African-American women below the age of 70. The most recent
data we've looked at suggest that, as with Caucasian women, this
These findings, he added, "suggest there is no reason we cannot
make the same kind of progress against this disease as we made
against testicular cancer, which is now curable in 90% of cases."
A Periodic Table for Biology?
Dr. Klausner noted that over the last quarter century, science had
made "slow but real progress in increasing cancer survival and
in increasing the number of individuals who are cured." And he
spoke enthusiastically of the potential for soon solving fundamental
questions about the cancer process as the result of advances in
genetics, microbiology, and understanding of the human genome.
He compared the state of cancer today to that of chemistry 100 years
ago. "For much of the 19th century, chemistry expanded by
empiricism until order was brought to the chaos of the physical
universe with the extraordinary recognition of the periodic
table," he said. "At the end of the 20th century, we
recognize very similarly that biological information is finite and
that we can, in fact, know it all.
"We are about to write down the periodic table of biology. It
will be the crowning achievement of medical research of this century.
It will not be written in rows and lines. It will be written as
branching trees whose connectedness and complete set of pieces will
allow us to finally solve basic biological puzzles."
The annual Oberstar lecture is named in honor of Jo Oberstar, a
professional development consultant, teacher, and advocate for women
in the workforce, who died of breast cancer in 1991.