BETHESDA, MdUsing new computer software to
mine existing databases, National Cancer Institute (NCI)
scientists have discovered 10,435 possible new variations in human
genes. The so-called single nucleotide polymorphisms, or SNPs, must
still be validated, but NCI said each of the variations met
statistical confidence levels of 0.99%.
SNPs are considered likely influences on how fast a cancer grows and
how well it responds to treatment. However, finding and understanding
the variations has posed a considerable technical challenge, one
eased somewhat by the special software used by the NCI scientists,
noted team leader Kenneth Buetow, PhD.
Information on the new SNPs is available free to researchers on the
NCIs Cancer Genome Anatomy Project website (http://lpg.nci.nih.gov).