Dr. William Brose, director of the Pain Management Center for
Stanford University, reported detailed study results from a chronic
pain study with SNX-111 at the American Pain Society on November
The paper, entitled, "Analgesia Produced by SNX-111 in Patients
With Morphine-Resistant Pain," represented the work from
multiple centers and described both the safety and efficacy of
SNX-111 in this study to treat patients with very severe pain.
SNX-111 is the lead pain therapeutic under development by Neurex
The majority of patients who were considered evaluable in this
study showed a measurable reduction in pain scores, as judged
by both patient and physician. In addition, most patients also
had a significant reduction in other medications that had been
used prior to the study in an attempt to treat, albeit unsuccessfully,
their pain symptoms.
Over two-thirds of the 24 patients had a 50% or greater reduction
in medication, with some patients totally eliminating morphine/narcotic
"Although the study was primarily designed to evaluate the
feasibility and efficacy of SNX-111 treatment in these severely
ill patients, it is clear that as a patient group, a majority
of these individuals seem to have benefited from improvements
in their pain symptoms with SNX-111 treatment," commented
"To see such a reduction in both their pain scores and use
of their pain medications in this patient population is quite
remarkable. For patients with prolonged and unremitting pain,
SNX-111 represents potential hope and light at the end of a very
long and dark tunnel."
The study evaluated the safety and efficacy of intraspinally administered
SNX-111 in patients who had previously failed morphine therapy.
Study guidelines required that patients had to have failed all
other pain treatment (including intraspinal morphine and other
narcotics) prior to study enrollment.
Patients entered into the study had various types of severe and
resistant pain, including those who were suffering from cancer,
AIDS, neuropathies, spinal cord injuries, and phantom limb pain.