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NIEHS Funds Six-Member Toxicogenomics Consortium

NIEHS Funds Six-Member Toxicogenomics Consortium

RESEARCH TRIANGLE, North Carolina—Five academic research centers
will join the National Institute of Environmental Health Sciences (NIEHS) to
form a consortium to study how genes interact with the environment to cause
cancer and other diseases, an emerging field known as toxicogenomics. Each of
the groups in the 5-year, $37 million program funded by the NIEHS will receive
grants totaling more than $7 million.

The consortium will work with NIEHS scientists and use genomics to determine
how disease occurs, identify potential environmental hazards, predict potential
disease, identify exposed individuals, and prevent disease. The consortium
members and their projects are as follows:

NIEHS: gene expression profiling to explore environmental stresses on
human health. This research group will make use of gene expression microarray
technology validation studies.

University of North Carolina at Chapel Hill: the study of
susceptibility factors in the genomic response to toxicants.

Fred Hutchinson Cancer Research Center: gene expression profiling in
transgenic mice and rats, and in human cell lines exposed to environmentally
relevant agents.

Oregon Health and Science University: cell-specific injury in the
central nervous system and gene profiling of induction mechanisms associated
with neurotoxicant exposures.

Duke University: gene expression profiling to explore environmental
stresses on human health.

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