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NSABP B-30: Amenorrhea relates to survival

NSABP B-30: Amenorrhea relates to survival

In a subset of 2,366 patients from NSABP B-30 with menstrual history available at follow-up, amenorrheic patients (≥ six months) had significantly improved overall and diseasefree survival across treatment arms. Mortality was significantly reduced by 24% and recurrence by 30%.

Of 2,111 patients with follow-up quality-of-life data, QOL (by FACT-B rating scale) and symptoms were essentially the same for all regimens at all time points. The exception was the six-month assessment, where patients receiving AC→T had significantly lower QOL and higher symptom scores, but both measurements later returned to baseline (abstract 75). Younger women had more severe symptoms independent of the development of amenorrhea. Persistent amenorrhea was least severe in the AT arm, reported Patricia Ganz, MD, of the University of California, Los Angeles.

“This information about quality of life, symptoms, and amenorrhea risk can be useful in making treatment decisions,” Dr. Ganz said, suggesting AT as an alternative for women in whom preservation of fertility is paramount over the modest improvement in survival.

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