ChromaVision Medical Systems, Inc, announced recently
that investigators using their automated cellular imaging system (ACIS)
concluded that the number of metastatic tumor cells found in the sentinel lymph
node correlates with the size of the primary breast tumor. The data, which were
presented at the 24th Annual San Antonio Breast Cancer Symposium, showed that
sentinel nodes from patients with small primary tumors have fewer tumor cells
and would require more extensive sectioning to detect metastases.
When cancer is diagnosed at an early stage, tumor analysis can be performed
while the tumor is still relatively small. According to ChromaVision, the ACIS
digital microscope platform makes it practical to examine a greater number of
lymph node sections than is possible by manual evaluation, thus improving the
feasibility of this type of testing and increasing the likelihood of detecting
any metastases that may be present. The ACIS system is designed to assist the
pathologist by detecting, counting, and classifying cells of clinical interest
based on the recognition of color, size, and shape.
Sentinel lymph node analysis, in which the first one to three lymph nodes to
receive drainage from the breast are tested for the presence of metastatic
cancer cells, is becoming increasingly popular. This analysis provides an
alternative to the traditional method of removing 20 to 30 lymph nodes from the
armpit. Up to 80% of women who undergo the more extensive surgery experience
mild to severe complications ranging from chronic pain to lymphedema.
New Level of Sensitivity
"The ability of the ACIS to rapidly and accurately detect rare tumor
cells brings a new level of sensitivity to lymph node analysis," said
principal investigator Kenneth J. Bloom, MD, assistant professor of pathology,
and director of laboratory operations at Rush Presbyterian-St. Luke’s Medical
Center in Chicago. "By using ACIS, physicians can more thoroughly analyze
sentinel nodes than is practical manually, and more accurately assess the true
stage or spread of a patient’s disease. In our laboratory at Rush, we use
the ACIS system not only in our research studies, but in the clinical
testing of a variety of breast cancer markers."