WASHINGTONRats with chemically induced colon cancer that were
fed orange juice for 4 weeks had a significantly lower incidence of
colon cancer tumors than those receiving water, in a study at
Michigan State University, East Lansing. Maurice R. Bennink, PhD,
professor of food science and human nutrition, presented the results
at the American Institute for Cancer Research 9th Annual Research
Previous studies have shown that certain flavanones, limonoids, and
cumarins present in citrus fruits can inhibit chemically induced
cancer in animals. But, Dr. Bennink said, it would be
inappropriate to extrapolate from these results with purified citrus
phytochemicals that consuming a citrus product such as orange juice
will inhibit cancer. The current study was designed to
determine if single-strength, pasteurized orange juice would inhibit
azoxymethane-induced colon cancer in male Fisher 344 rats.
The researchers replaced drinking water with orange juice in the
diets of the experimental group of 30 rats for 28 weeks. Growth and
weight gain were similar in both groups during the study, but feeding
orange juice to the rats reduced tumor incidence by 22%.
Tropicana Products, Inc. provided Tropicana Pure Premium orange juice
and financial support for the study.