NEW ORLEANSThe survival rate for patients with primary invasive epithelial
ovarian cancer has steadily increased over the past 3 decades, despite rising
diagnoses among African-American women and women over age 60, according to an
analysis presented at the Society of Gynecologic Oncologists’ 34th annual
meeting (abstract 3).
Researchers from Wayne State University, Detroit, presented their findings
regarding the patterns of diagnosis and relative survival in women diagnosed
with the cancer from 1973 to 1997, with follow-up through 1999. In 2002, an
estimated 23,100 new cases are expected. While the incidence of the disease
remains unchanged, mortality has decreased, the study found.
Lead investigator Adnan R. Munkarah, MD, associate professor and director,
Division of Gynecologic Oncology, Wayne State University, attributed the
improvements to better medical care in general, improved access to care for
minorities and the underprivileged, and improved survival among acutely ill
patients. The concept of surgical staging and more appropriate treatments,
including the addition of taxanes to chemotherapy regimens, have also had an
impact, he said.
The population was drawn from the Surveillance, Epidemiology and End Results
Program (SEER) database covering the 3 decades and involving 32,845 women
diagnosed with invasive epithelial ovarian cancer during that time.
The study found that overall relative survival has continuously improved.
The 2-year survival rate improved significantly, from 49% in 1973-1979 to 62%
for the period 1990-1997. The 5-year survival rate increased slightly over the
3 decades, from 37% for the period 1973-1979, to 39% for 1980-1989, to 43% for
1990-1997, Dr. Munkarah reported.
However, patients age 70 and older and those of African-American ethnicity
continue to have the worst relative survival, with 5-year survival rates of 26%
and 37%, respectively, for the most recent period, and no improvements over the
3 decades. This is an important issue, he noted, since the population of women
aged 70 and older represents 36% of ovarian cancer diagnoses.
Increases have been observed in the proportions of diagnoses among ethnic
minorities and among women over 60 years of age at the time of diagnosis. There
has not been a clinically significant change in the distribution of tumors by
histology, he added.