TARRYTOWN, New YorkAton Pharma, Inc and its collaborators presented phase
I data on its oral histone deacetylase inhibitor SAHA (suberoylanilide
hydroxamic acid) at the 14th Annual EORTC/NCI/AACR symposium, held in
Frankfurt, Germany. The trial of patients with refractory solid tumors,
lymphomas, and leukemias, being conducted with researchers at Memorial Sloan-Ket-tering
Cancer Center, defined a safe daily oral dosing regimen.
Evidence of antitumor activity was also observed. Of the 28 patients with
solid tumors, one (larynx cancer) had a partial response, two (renal cell
cancer and transitional cell cancer) had reduction in measurable disease, and
one (papillary thyroid cancer) had stable disease for more than 2 months.