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Polyglutamate-Paclitaxel Controls Recurrent Ovarian Cancer

Polyglutamate-Paclitaxel Controls Recurrent Ovarian Cancer

ORLANDO—Interim
results from a phase I/II clinical trial of patients with recurrent ovarian,
fallopian tube, or peritoneal cancer show that polygutamate (PG)-paclitaxel
(CT-2103, Xyotax) controlled disease in about half of the evaluable patients.

Less Toxic, More Selective

Paul Sabbatini, MD, of Memorial Sloan-Kettering Cancer
Center, presented the interim findings in a poster at the 38th Annual Meeting
of the American Society of Clinical Oncology (abstract 871). The investigators
concluded that CT-2103, a less-toxic, more-selective form of paclitaxel (Taxol),
is active as a single agent in recurrent ovarian cancer and warrants further
study.

"We have stable disease in patients who progressed on Taxol
therapy," Dr. Sabbatini told ONI. He emphasized that most of the 89
patients in the trial had been heavily pretreated, failing as many as nine
prior chemotherapy regimens.

Among 43 patients evaluable for response, CT-2103 was more
effective in the 22 patients with platinum-sensitive disease. It produced a
partial response in five of these patients (23%) and stable disease in eight
(36%), providing disease control in 59% of patients. Of the 21 patients who
were platinum resistant or refractory, one patient (5%) had a partial response,
and eight (38%) had stable disease. In all, 51% of patients evaluated for
response achieved disease control with the experimental agent.

Median progression-free survival at 9.5 months of follow-up
was 4.0 months for platinum-sensitive patients and 3.1 months for
platinum-resistant/refractory patients.

Cell Therapeutics Inc. in Seattle supported the ongoing
phase I/II study. It is being conducted at seven cancer centers, and 29 of the
88 patients who began treatment were still receiving treatment at the time of
the ASCO presentation.

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