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Preliminary Phase III Results for Provenge Vaccine in Prostate Cancer

Preliminary Phase III Results for Provenge Vaccine in Prostate Cancer

SEATTLE—Dendreon Corporation has announced preliminary results from its analysis of its randomized, double-blind, placebo-controlled phase III study of Provenge (APC 8015) for the treatment of hormone-resistant prostate cancer. The trial of the cancer vaccine (D9901) involved 127 men with late-stage, metastatic, hormone-resistant prostate cancer, 82 of whom received Provenge, three vaccinations over a 4-week period.

The vaccine utilizes a recombinant form of prostatic acid phosphatase (PAP), an antigen found in 95% of prostate cancers.

The results showed that men with a Gleason score of 7 or less significantly benefited from Provenge in terms of time to disease progression.

 
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