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Radiotherapy Not Needed in Older Lumpectomy Patients With Early Cancer

Radiotherapy Not Needed in Older Lumpectomy Patients With Early Cancer

SAN FRANCISCO—Preliminary results of a randomized Intergroup trial
(CALGB, RTOG, ECOG) strongly suggest that radiotherapy should not be added to
tamoxifen (Nolvadex) in older women who have undergone lumpectomy for
early-stage breast cancer, said Kevin S. Hughes, MD, Department of Surgical
Oncology, Massachusetts General Hospital, Boston.

Speaking at the 37th American Society of Clinical Oncology annual meeting
(abstract 93), Dr. Hughes reported data comparing tamoxifen plus radiotherapy
with tamoxifen alone in 647 women (636 eligible), age 70 and older, with
estrogen-receptor (ER) positive tumors who had undergone lumpectomy.

"Radiation therapy may not have clinical benefit or an impact on
survival in this population," Dr. Hughes stated. "In older patients,
tumors tend to grow more slowly, and there is a lower risk of in-breast
recurrence and a shorter time at risk. Data show that the standard of care
should remain unchanged for these women at this period of follow-up."

Dr. Hughes reported that with a median follow-up of 28 months, the rate of
locoregional failure was very low in both treatment groups and not
significantly different.

Of 317 patients receiving radiotherapy plus tamoxifen, none had a
locoregional occurrence, compared with 6 of 319 patients on tamoxifen alone.

"The combination of tamoxifen plus radiotherapy may be superior for
controlling locoregional breast cancer recurrences," Dr. Hughes said.
"Longer follow-up is needed to fully assess whether this decrease is
clinically important."

The rates of distant metastasis, eventual mastectomy, and contralateral
breast cancer were similar in both arms.

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