We've noticed that you're using an ad blocker

Our content is brought to you free of charge because of the support of our advertisers. To continue enjoying our content, please turn off your ad blocker.

It's off now Dismiss How do I disable my ad blocker?
❌

How to disable your ad blocker for our site:

Adblock / Adblock Plus
  • Click on the AdBlock / AdBlock Plus icon on the top right of your browser.
  • Click “Don’t run on pages on this domain.” OR “Enabled on this site.”
  • Close this help box and click "It's off now".
Firefox Tracking Prevention
  • If you are Private Browsing in Firefox, "Tracking Protection" may casue the adblock notice to show. It can be temporarily disabled by clicking the "shield" icon in the address bar.
  • Close this help box and click "It's off now".
Ghostery
  • Click the Ghostery icon on your browser.
  • In Ghostery versions < 6.0 click “Whitelist site.” in version 6.0 click “Trust site.”
  • Close this help box and click "It's off now".
uBlock / uBlock Origin
  • Click the uBlock / uBlock Origin icon on your browser.
  • Click the “power” button in the menu that appears to whitelist the current website
  • Close this help box and click "It's off now".
  • ONCOLOGY
  • News
  • Blogs
  • Topics
  • Hematology
  • Image IQ
  • Podcasts
  • Videos
  • Slideshows
  • Conferences

Modern Medicine Network
  • Login
  • Register
Skip to main content
Modern Medicine Network
  • Login
  • Register
Menu
User
Home
  • ONCOLOGY
  • News
  • Blogs
  • Topics
  • Hematology
  • Image IQ
  • Podcasts
  • Videos
  • Slideshows
  • Conferences

SUBSCRIBE: Print / eNewsletter

Statins during RT may lower risk of prostate ca relapse

Jan 1, 2008
Volume: 
17
Issue: 
1
  • Prostate Cancer, Prostate Cancer

LOS ANGELES—Men who have undergone high-dose radiation therapy for prostate cancer have a reduced risk of relapse if they were taking statins during their radiation therapy, finds a retrospective study reported at the 2007 ASTRO annual meeting (abstract 203). The benefit was greatest among those men with high-risk disease.

"There are some studies that have shown or suggested that statins may interfere with antiapoptotic pathways and may, in fact, act as radiation sensitizers in experimental tumor models," said senior author Michael J. Zelefsky, MD, of Memorial Sloan-Kettering Cancer Center.

The researchers assessed associations between use of statins during high-dose 3D conformal/intensity-modulated radiation therapy (75.6 to 86.4 Gy) and various outcomes among 871 men with clinical stage T1c to T3 prostate cancer treated between 1994 and 2000 at the center.

Nineteen percent of the patients were taking a statin at the time of diagnosis and continued to do so during radiation therapy, Dr. Zelefsky said. Some 29% had favorable-risk disease, 46% had intermediate-risk disease, and 25% had high-risk disease. About half (54%) were treated with neoadjuvant hormonal therapy.

Improved relapse-free survival

With a median follow-up of 7 years, the 10-year estimated probability of survival free of a PSA relapse was significantly higher among the statin users than among the nonusers overall (76% vs 66%), Dr. Zelefsky said.

By risk category, the difference was marginal among the intermediate-risk group (P = .07) and significant among the high-risk group (P = .005).

Pages

  • 1
  • 2
  • next ›
  • last »

Related Articles

  • Prostate Cancer Screening in African-American Men
  • No Improved Outcomes in Prostate Cancer With ADT Plus Mitoxantrone/Prednisone
  • No Benefit in Outcomes With Higher Resource Use in Metastatic Prostate Cancer
  • Proton RT for Prostate Cancer Has Reduced Toxicity, Higher Cost vs Other RT Options
  • ‘Screening Smarter’ for Prostate Cancer

Resource Topics rightRail

  • Resource Topics
  • Partner Content
Breast Cancer
Lung Cancer
Prostate Cancer
Colorectal Cancer
Melanoma
Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sézary Syndrome
3 Keys to Success in the Oncology Care Model

Current Issue

Oncology Vol 32 No 4
Apr 15, 2018 Vol 32 No 4
Digital Edition
Subscribe
Connect with Us
  • Twitter
  • Facebook
  • LinkedIn
  • RSS
Modern Medicine Network
  • Home
  • About Us
  • Advertise
  • Advertiser Terms
  • Privacy statement
  • Terms & Conditions
  • Editorial & Advertising Policy
  • Editorial Board
  • Contact Us
Modern Medicine Network
© UBM 2018, All rights reserved.
Reproduction in whole or in part is prohibited.