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Studies Explore Optimal Treatment for DCIS, Markers for High Recurrence Risk

Studies Explore Optimal Treatment for DCIS, Markers for High Recurrence Risk

SAN ANTONIO--Searches for high-risk markers may ultimately point
the way toward the optimal use of breast-conserving surgery for
ductal carcinoma in situ (DCIS); early findings from one study,
for example, suggest that a family history of breast cancer may
militate against such surgery.

Breast-conserving surgery offers a high degree of local control
for DCIS, but questions remain about long-term risks and optimal
candidates, Jay R. Harris, MD, said at a plenary session of the
San Antonio Breast Cancer Symposium. The risk of recurrence after
conservative surgery for DCIS appears slightly increased, and
half the recurrences will be invasive, he said. A critical unresolved
issue is the salvage rate for recurrences.

"We need more long-term data to know exactly what the additional
risk is with breast conservation," said Dr. Harris, professor
of radiation oncology, Harvard Medical School. "Maybe we
need to refocus our energies and try to separate out those high-risk
DCIS patients who need to be treated aggressively."

As an example, he cited a Harvard study of angiogenesis in DCIS.
About a third of 55 consecutive patients had one of two distinct
patterns of vessel proliferation: a diffuse pattern and a pattern
of "vascular cuffing" around the involved duct. "It's
possible that one or both of these patterns are predictive of
a more aggressive natural history," Dr. Harris commented.

Family History as a Risk Factor

Family history has emerged unexpectedly as a potential risk factor
for recurrence among women treated conservatively for DCIS. In
an ongoing study at Harvard, 17 patients had a family history
of breast cancer. Four have had recurrent disease, and in all
four cases, the recurrence has been invasive.

By comparison, disease has recurred in three of 58 women without
a family history of breast cancer, and only one of the recurrences
was invasive.

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