(Campath-1H) administered subcutaneously produced an overall response rate of
87% among 38 patients with previously untreated chronic lymphocytic lymphoma (CLL)
in a phase II study conducted at the Karolinska Institute in Stockholm.
The complete response rate was 95% in the blood and 45% in
the bone marrow. An additional 34% had a partial response in the bone marrow,
for an overall response of 79%. "Prolonged treatmentup to 18 weeksappears to
be important to achieve high-quality bone marrow remissions," Jeanette Lundin,
MD, of the Karolinska Institute, noted in her presentation at the 43rd Annual
Meeting of the American Society of Hematology (abstract 3215). The response
rate for lymphadenopathy was 87%.
Up to 18 weeks of alemtuzumab was administered at escalated
doses of 3 to 10 to 30 mg, three times a week. "The majority of the patients
had advanced disease," Dr. Lundin said. The 38 evaluable patients (out of 41
enrolled) received at least 2 weeks of therapy. The median time to treatment
failure had not yet been reached at the time of the presentation (18+ months).
Adverse Events Mostly Mild
Adverse events were mostly mild and resolved with treatment.
Prophylaxis with acyclovir, trimethoprim sulfamethoxa-zole, and fluconazole (Diflucan)
was given. Most patients had transient grade 1-2 fever but few other first-dose
reactions. Local injection site reactions (grade 1-2) occurred during the first
1 to 2 weeks of therapy in most patients.
Transient grade 4 neutropenia was recorded in 24% of
patients. Four patients had cytomegalovirus (CMV) reactivation causing fever
with pneumonitis. They promptly responded to intravenous therapy with
ganciclovir (Cytovene). In two of these patients, alemtuzumab was restarted
without recurrence of CMV. One patient who was allergic to
trimethoprim-sulfamethoxazole had a Pneumocystis carinii pneumonia
Subcutaneous administration was well tolerated and could be used not only
for alemtuzumab but also for other monoclonal antibodies, the researchers said,
with benefits such as reduced costs and home self-administration. Campath-1H is
currently available only for administration as a 2-hour IV infusion. The study
was also reported in the August issue of Blood [100(3):768-773, 2002].