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Two Teams Report Gene Linked to Basal Cell Carcinoma

Two Teams Report Gene Linked to Basal Cell Carcinoma

BETHESDA, Md--Research supported by the National Institutes of Health and the National Cancer Institute has led to discovery of a tumor-suppressor gene involved in basal cell carcinoma.

The findings were reported by an international team from the United States, Sweden, and Australia in Cell, and by a California-based team in Science.

The gene, known as patched (PTC), is implicated in the nevoid basal cell carcinoma syndrome, a rare disorder that causes numerous birth defects and an inherited form of basal cell carcinoma. It also appears to play a role in sporadic basal cell carcinoma, since mutations of the gene were also found in a few patients with noninherited basal cell tumors.

 
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