BETHESDA, MdThe newest version of Guidelines for the Use
of Antiretroviral Agents in HIV-Infected Adults and Adolescents
is now available on the Internet at www.hivatis.org. The update
includes recommendations about the use of Ziagen (abacavir), which
can be given in combination with Retrovir (zidovudine) and Epivir
(lamivudine). All three drugs are nucleoside analog reverse
However, the panel that created the guidelines is concerned about the
ability of this three-drug regimen to adequately suppress HIV
replication in individuals with high baseline levels of plasma viral
load, said co-chair John G. Bartlett, MD, of Johns Hopkins
Medical Center. Thus, it recommends the Ziagen-Retrovir-Epivir
combination be considered an alternative to other
regimens described in the guidelines.
The guidelines are a joint effort by the US Department of Health and
Human Services and the Henry J. Kaiser Family Foundation.