We've noticed that you're using an ad blocker

Our content is brought to you free of charge because of the support of our advertisers. To continue enjoying our content, please turn off your ad blocker.

It's off now Dismiss How do I disable my ad blocker?
❌

How to disable your ad blocker for our site:

Adblock / Adblock Plus
  • Click on the AdBlock / AdBlock Plus icon on the top right of your browser.
  • Click “Don’t run on pages on this domain.” OR “Enabled on this site.”
  • Close this help box and click "It's off now".
Firefox Tracking Prevention
  • If you are Private Browsing in Firefox, "Tracking Protection" may casue the adblock notice to show. It can be temporarily disabled by clicking the "shield" icon in the address bar.
  • Close this help box and click "It's off now".
Ghostery
  • Click the Ghostery icon on your browser.
  • In Ghostery versions < 6.0 click “Whitelist site.” in version 6.0 click “Trust site.”
  • Close this help box and click "It's off now".
uBlock / uBlock Origin
  • Click the uBlock / uBlock Origin icon on your browser.
  • Click the “power” button in the menu that appears to whitelist the current website
  • Close this help box and click "It's off now".
  • ONCOLOGY
  • News
  • Blogs
  • Topics
  • Hematology
  • Image IQ
  • Podcasts
  • Videos
  • Slideshows
  • Conferences

Modern Medicine Network
  • Login
  • Register
Skip to main content
Modern Medicine Network
  • Login
  • Register
Menu
User
Home
  • ONCOLOGY
  • News
  • Blogs
  • Topics
  • Hematology
  • Image IQ
  • Podcasts
  • Videos
  • Slideshows
  • Conferences

SUBSCRIBE: Print / eNewsletter

VTD induction boosts CRs in newly diagnosed myeloma

Feb 1, 2008
Volume: 
17
Issue: 
2
  • Multiple Myeloma, Multiple Myeloma

ATLANTA—In patients with newly diagnosed multiple myeloma, the addition of bortezomib (Velcade) to thalidomide (Thalomid) and dexamethasone significantly increased response rates, compared with thalidomide plus dexamethasone alone, when used as induction therapy prior to autologous stem cell transplant (ASCT). Michele Cavo, MD, of the Sergnoli Institute of Hematology, University of Bologna, Italy, presented the interim results of the phase III trial at ASH 2007 (abstract 76) on behalf of the Italian Myeloma Network (GIMEMA).

All patients received three 21-day courses of induction therapy prior to ASCT. The VTD regimen consisted of bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11, plus dexamethasone 40 mg on each day of and after bortezomib administration. Thalidomide was dosed at 200 mg/d from days 1 to 63. Patients on the thalidomide/dexamethasone (TD) regimen received thalidomide as in the VTD arm and dexamethasone 40 mg/d on days 1-4 and 9-12, every 21 days.

Both regimens were administered before (induction) and after (consolidation) double ASCT with melphalan 200 mg/m2. The primary endpoint was complete response to induction therapy, either immunofixation negative (CR) or immunofixation positive (nCR).

Dr. Cavo reported on the first 256 patients. By intent-to-treat analysis, addition of bortezomib resulted in a significantly greater CR/nCR rate, compared with TD alone (36% vs 9%, P < .001).

"Complete remission is widely recognized as a predictor for long-term survival," Dr. Cavo commented.

Adverse events of grade 3 or higher were similar between the two groups.

In a subset of patients for whom longer follow-up was available, post-ASCT complete response rates were significantly higher for patients on the bortezomib-containing regimen, compared with the TD regimen (57% vs 28%, P < .001).

Pages

  • 1
  • 2
  • next ›
  • last »

Related Articles

  • Excess Mortality Risk Shows Myeloma Is Still ‘Incurable’
  • High BMI in Early Adulthood Increased Myeloma Risk
  • Ixazomib Triplet Combo Effective in R/R Myeloma
  • Pomalidomide/Dexamethasone Effective in R/R Myeloma With Renal Insufficiency
  • Denosumab Approved for Skeletal-Related Events in Myeloma

Resource Topics rightRail

  • Resource Topics
  • Partner Content
Breast Cancer
Lung Cancer
Prostate Cancer
Colorectal Cancer
Melanoma
Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sézary Syndrome
3 Keys to Success in the Oncology Care Model

Current Issue

Oncology Vol 32 No 4
Apr 15, 2018 Vol 32 No 4
Digital Edition
Subscribe
Connect with Us
  • Twitter
  • Facebook
  • LinkedIn
  • RSS
Modern Medicine Network
  • Home
  • About Us
  • Advertise
  • Advertiser Terms
  • Privacy statement
  • Terms & Conditions
  • Editorial & Advertising Policy
  • Editorial Board
  • Contact Us
Modern Medicine Network
© UBM 2018, All rights reserved.
Reproduction in whole or in part is prohibited.