SAN DIEGOWheat bran fiber does not appear to reduce the
recurrence of colorectal adenomas, Richard E. Sampliner, MD, said at
the American Gastroenterological Association annual meeting, held
during the Digestive Disease Week conference. Dr. Sampliner is
professor of medicine and chief of gastroenterology, University of
Arizona Health Sciences Center, Tucson.
The Arizona researchers conducted a prospective, randomized,
double-blind placebo-controlled trial of wheat brain fiber in 1,429
patients, aged 40 to 80, who had had a confirmed colorectal adenoma
larger than 3 cm removed within the past 3 months.
One group was given 13.5 g/d of wheat bran fiber while the other
received only 2 g/d. At the end of the 3-year trial, 1,303
participants had at least one endpoint colonoscopy. One or more
adenomas were detected in 47% of the high-fiber group vs 51% of the
There was no significant difference in recurrence rate between
the two groups, Dr. Sampliner said. He also noted that those
individiuals on the high-fiber diet were more likely to complain of
abdominal pain, diarrhea, intestinal gas, and bloating.
Dr. Sampliner speculated that the amount of fiber consumed by the
high-fiber group may have been insufficient to show a benefit and
that the timing in relation to the development of neoplasia may not
have been appropriate.