Pembrolizumab Plus Reduced Ipilimumab Dose Active in Advanced Melanoma
Standard-dose pembrolizumab with four reduced doses of ipilimumab followed by standard-dose pembrolizumab had a manageable safety profile and antitumor activity in patients with advanced melanoma.
Ibrutinib Approval Expanded to Include Chronic GVHD
The US Food and Drug Administration has approved the tyrosine kinase inhibitor ibrutinib (Imbruvica) for adult patients with chronic graft vs host disease who have failed on one or more lines of prior systemic therapy.
FDA Announces Plan to Lower Nicotine in Cigarettes to Non-Addictive Levels
The FDA has announced a new comprehensive plan for tobacco and nicotine regulation designed to serve as a road map to better protect American children and reduce tobacco-related disease and death.
Obesity in Adolescence Linked With Subsequent Colorectal Cancer
Overweight and obesity in adolescence were associated with an increased risk for colon cancer later in life among both men and women, according to the results of a recent study.
Adherence to Quality Metrics Could Improve Head and Neck Cancer Survival
Adherence to each of five quality metrics for head and neck squamous cell carcinoma was associated with a reduced risk for death.
Low-Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies
A lower dose of rabbit anti–T-lymphocyte globulin was superior to a higher dose in children with hematologic malignancies undergoing transplant from an unrelated donor.
Adherence to Distress Screening Protocols Lacking
Adherence to screening protocols at cancer centers resulted in fewer emergency department visits and hospitalizations in the 2-month period after the screening.
Immunotherapy Combination in Metastatic RCC Proves Effective
Patients with metastatic renal cell carcinoma had durable responses and manageable safety when treated with the combination of nivolumab and ipilimumab.
FDA Clears Test to Help Diagnose, Identify Blood Cancer Type
The FDA has approved the marketing of a new lab test used with flow cytometry to aid in the detection of several types of hematologic malignancies.
Increased Node Dissection Improved Survival in Node-Negative Oral Cavity SCC
Higher nodal yield during definitive surgery for clinically node-negative oral cavity squamous cell carcinoma was associated with improved mortality.
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