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Although important questions still remain regarding chemotherapy choice, sequence, and dosing, the answers to which will require additional large phase III trials, radiotherapy alone is no longer appropriate therapy for 1p/19q codeleted anaplastic oligodendrogliomas.
Here we present the history, staging system, and treatment of medulloblastoma, reviewing the prognostic value and clinical application of molecular subtyping while highlighting the differences between adult and pediatric disease.
This review will focus on the breast cancer subtypes with the highest incidence of breast cancer brain metastases—HER2-positive breast cancer, and triple-negative breast cancer—and will characterize differences in the clinical behavior of brain metastases that arise from these different subtypes.
The development of metastatic disease in patients with paraganglioma is an unusual and challenging event. This case report and review describes the specific features of this disease and the multiple therapeutic options.
The authors address several commonly cited beliefs that have hindered the development of therapeutic agents for central nervous system malignancies, and advance reasons that they feel justify including patients with brain metastases in clinical trials of new therapeutic approaches for lung cancer.
A healthy 24-year-old male presented with a history of several months of poorly localized headaches and blurred vision. MRI of the brain demonstrated a multi-lobulated mass. Based on the radiographic appearance of the mass, what is the most likely diagnosis?
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