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Brain Tumors

Current and Emerging Treatments for Brain Metastases

Jenny Lin, BA, Rahul Jandial, MD, PhD, Amanda Nesbit, BS, et al; ONCOLOGY Vol. 29; No. 4
Conventional methods for treating brain metastasis, such as surgery, WBRT, and SRS, each compete with and complement one another. A plethora of recent studies have helped define and expand the utility of these tools.

Brain Tumors

A new genetic analysis found five new genetic variants that raise the risk for gliomas. One of the five was associated with a sharply increased risk for glioblastoma.

A genomic analysis of the primary tumors and brain metastases of patients has revealed potentially targetable mutations only present in the brain metastases.

A new meta-analysis found that adiposity is linked to an increased risk of meningioma, but is unrelated to glioma risk; and physical activity is linked to a lower risk for meningioma.

Gross total resection was associated with significantly lower all-cause mortality in patients with atypical and malignant meningioma, according to a new study.

Often excluded from early trials, adults with high-grade gliomas may be good candidates for solid tumor phase I studies of single agents, according to a new analysis.

Whole brain radiation therapy helps control tumor growth in patients with 1 to 3 small brain metastases, but it does not significantly extend patient survival.

Meningiomas are the most common primary brain tumor and comprise nearly one-third of all newly diagnosed primary brain tumors.


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