A study shows that LKB1 deficiency in T cells increases gastrointestinal polyposis development.
Cancer and Genetics
Study shows that ctDNA levels measured by targeted deep sequencing sensitively indicate the presence of cancer.
Oncologists should refer patients who want traditional genetic counseling and/or have preexisting psychosocial factors that would increase risk of an adverse psychological outcome of counseling.
In analyzing over 8,300 mosaic chromosomal alterations in UK Biobank participants, Harvard researchers uncovered specific alterations that may predict for CLL.
Brazilian researchers say their study results “suggest the overall DNA methylation profile may be influenced by the histological subtype of thyroid cancer.”
Strong efficacy and safety outcomes with this agent, which targets the molecular driver of an AML subset, have led to its approval in IDH1-mutated R/R disease.
A team of Texas-based oncologists says their preclinical study results “demonstrate that IGF-1R and FOXC1 seem to positively regulate each other.”
Oncologist Dr. Vivek Subbiah and computer scientist Dr. Jason Roszik, both from MD Anderson, discuss optimizing “omics” databases to inform cancer patient care.
DNA and RNA sequencing results suggest prostate cancer treatment “involving inhibition of CDK12 and immune checkpoint blockade,” a U Michigan team said.
This study is the first to show significantly improved OS from single-agent treatment in this particularly difficult to treat population.