12th EDITION

Cancer Management:
A Multidisciplinary Approach

Medical, Surgical & Radiation Oncology

Edited by Richard Pazdur, MD Director, Office of Oncology Drug Products Center for Drug Evaluation and Research US Food and Drug Administration Lawrence D. Wagman, MD Executive Medical Director The Center for Cancer Prevention and Treatment St. Joseph Hospital Kevin A. Camphausen, MD Chief, Radiation Oncology Branch National Cancer Institute William J. Hoskins, MD Executive Director of Surgical Activities Memorial Sloan-Kettering Cancer Center And the publishers of the journal ONCOLOGY

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Contributors

Preface
Richard Pazdur, Lawrence D. Wagman, Kevin A. Camphausen, and William J. Hoskins

About This Treatment Guide
Content provided in this 12th edition was released in 2009. New clinical data announced since that time will be included in an updated 12th edition of "Cancer Management: A Multidisciplinary Approach."

Title Page

cancers of the head and neck region

Ch 1 Head and neck tumors
John Andrew Ridge, Bonnie S. Glisson, Miriam N. Lango, and Steven Feigenberg

Ch 2 Thyroid and parathyroid cancers
Mimi I. Hu, Peter Ahn, and Jeffrey P. Lamont

LUNG CANCER

Ch 3 Non-small-cell lung cancer
Benjamin Movsas, Fadlo R. Khuri, and Kemp H. Kernstine

Ch 4 Small-cell lung cancer, mesothelioma, and thymoma
Bonnie S. Glisson, Benjamin Movsas, and Walter Scott

Breast cancer

Ch 5 Breast cancer overview Risk factors, screening, genetic testing, and prevention
Lori Jardines, Sharad Goyal, Paul Fisher, Jeffrey Weitzel, and Melanie Royce

Ch 6 Stages 0 and I breast cancer
Lori Jardines, Sharad Goyal, and Melanie Royce

Ch 7 Stage II breast cancer
Lori Jardines, Sharad Goyal, and Melanie Royce

Ch 8 Stages III and IV breast cancer
Lori Jardines, Sharad Goyal, Melanie Royce, and Ishmael Jaiyesimi

GASTROINTESTINAL CANCERS

Ch 9 Esophageal cancer
Jimmy J. Hwang, Rajesh V. Iyer, and Michael Mulligan

Ch 10 Gastric cancer
Charles D. Blanke, Deborah Citrin, and Roderich E. Schwarz

Ch 11 Pancreatic, neuroendocrine GI, and adrenal cancers
Al B. Benson III, Robert J. Myerson, and Aaron Sasson

Ch 12 Liver, gallbladder, and biliary tract cancers
Lawrence D. Wagman, John M. Robertson, Laura Raftery, and Bert O'Neil

Ch 13 Colon, rectal, and anal cancers
Steven R. Alberts, Deborah Citrin, Miguel Rodriguez-Bigas, and Prajnan Das

GENITOURINARY MALIGNANCIES

Ch 14 Prostate cancer
Judd W. Moul, Andrew J. Armstrong, Brent K. Hollenbeck, Joseph Lattanzi, Deborah Bradley, and Maha Hussain

Ch 15 Testicular cancer
Patrick J. Loehrer, Nagesh Jayaram, Atreya Dash, Mark K. Buyyounouski, and Douglas Skarecky

Ch 16 Urothelial and kidney cancers
Mark Hurwitz, Philippe E. Spiess, Brian Rini, and Louis L. Pisters

GYNECOLOGIC MALIGNANCIES

Ch 17 Cervical cancer
Niyati Nadkarni, Carlos A. Perez, William Tew, and Sharmila Makhija

Ch 18 Uterine corpus tumors
Kathryn M. Greven, Maurie Markman, and David Scott Miller

Ch 19 Ovarian cancer
Stephen C. Rubin, Paul Sabbatini, and Akila N. Viswanathan

SKIN CANCERS

Ch 20 Melanoma and other skin cancers
Mary S. Brady, Aradhana Kaushal, Christine Ko, and Keith Flaherty

Sarcomas

Ch 21 Bone sarcomas
Alan W. Yasko, Warren Chow, and Deborah Frassica

Ch 22 Soft-tissue sarcomas
Peter W. T. Pisters, Mitchell Weiss, and Robert Maki

Brain TUMORS

Ch 23 Primary and metastatic brain tumors
Lisa M. DeAngelis, Jay S. Loeffler, and Adam N. Mamelak

other SOLID TUMORS

Ch 24 AIDS-related malignancies
Ronald T. Mitsuyasu and Jay S. Cooper

Ch 25 Carcinoma of an unknown primary site
John D. Hainsworth and Lawrence M. Weiss

hematologic malignancies

Ch 26 Hodgkin lymphoma
Joachim Yahalom and David Straus

Ch 27 Non-Hodgkin lymphoma
Andrew M. Evens, Jane N. Winter, Leo I. Gordon, Brian C.-H. Chiu, Richard Tsang, and Steven T. Rosen

Ch 28 Multiple myeloma and other plasma cell dyscrasias
Sundar Jagannath, Paul Richardson, and Nikhil C. Munshi

Ch 29 Acute leukemias
Margaret R. O'Donnell

Ch 30 Chronic myeloid leukemia
Jorge E. Cortes, Richard T. Silver, and Hagop Kantarjian

Ch 31 Chronic lymphocytic leukemia
William G. Wierda, Nicole Lamanna, and Mark A. Weiss

Ch 32 Myelodysplastic syndromes
Guillermo Garcia-Manero, Alan List, Hagop Kantarjian, and Jorge E. Cortes

Ch 33 Hematopoietic cell transplantation
Stephen J. Forman

Palliative and SUPPORTIVE CARE

Ch 34 Pain management
Sharon M. Weinstein, Penny R. Anderson, Alan W. Yasko, and Lawrence Driver

Ch 35 Management of nausea and vomiting
Steven M. Grunberg, Masanori Mori, and Richard Gralla

Ch 36 Depression, anxiety, and delirium
Ilana Braun

Ch 37 Fatigue and dyspnea
Sriram Yennurajalingam and Eduardo Bruera

Ch 38 Anorexia and cachexia
Charles Loprinzi and Aminah Jatoi

COMPLICATIONS

Ch 39 Oncologic emergencies and paraneoplastic syndromes
Carmen P. Escalante, Ellen Manzullo, and Mitchell Weiss

Ch 40 Infectious complications
James Ito, Sanjeet Dadwal, and Jane Kriengkauykiat

Ch 41 Fluid complications
Frederic W. Grannis, Jr., Carey A. Cullinane, Lily Lai, Casandra Anderson, Minia Hellan

Color Atlases

Color atlas 1: The ABCDEs of moles and melanomas

Color atlas 2: Skin lesions

Color atlas 3: Dermatologic toxicities associated with targeted therapies
 

APPENDICES

Appendix 1: Response evaluation criteria and performance scales

Appendix 2: Cancer information on the Internet
J. Sybil Biermann

Appendix 3: Cancer drugs and indications newly approved by the US Food and Drug Administration

Appendix 4: Chemotherapeutic agents and their uses, dosages, and toxicities

Emiliano Calvo, MD, PhD and Antonio Calles, MD