The chemotherapeutic agents included in this Appendix are classified by mechanism of action and are organized as follows:

• alkylating agents;

• antimetabolites;

• natural products;

• targeted agents

– monoclonal antibodies

– molecularly targeted therapies

FDA-approved uses and dose-limiting effects are set in italic type for emphasis.

 

Abbreviations: ALL = acute lymphoblastic leukemia; AML = acute myelogenous leukemia; AUC = area under the curve; BMT = bone marrow transplantation; CLL = chronic lymphocytic leukemia; CML = chronic myelogenous leukemia; CMML = chronic myelomacrocytic leukemia; EGFR = epidermal growth factor receptor; 5-FU = fluorouracil; GFR = glomerular filtration rate; GIST = gastrointestinal stromal tumor; HL = Hodgkin lymphoma; MDS = myelodysplastic syndromes; MOPP = mechlor-ethamine, Oncovin, procarbazine, and prednisone; NHL = non-Hodgkin lymphoma; NSCLC = non–small-cell lung cancer; SCLC = small-cell lung cancer; SIADH = syndrome of inappropriate antidiuretic hormone secretion; WBC = white blood cell