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Home » Cancer Management: A Multidisciplinary Approach

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CANCER MANAGEMENT: ONLINE EDITION 

Bone Sarcomas

By Warren Chow, MD1, Karl Haglund, MD, PhD2, R. Lor Randall, MD, FACS3 | May 15, 2013
1Department of Medical Oncology and Therapeutics Research/Department of Molecular Pharmacology, City of Hope National Medical Center 2Radiation Oncology Branch, National Cancer Institute 3Sarcoma Service, Huntsman Cancer Institute, University of Utah

  • TABLE OF CONTENTS
  • Overview
  • Epidemiology
  • Etiology and Risk Factors
  • Signs and Symptoms
  • Screening and Diagnosis
  • Pathology
  • Staging and Prognosis
  • Treatment
  • Suggested Reading

Suggested Reading

Anderson P, Aguilera D, Pearson M, et al: Outpatient chemotherapy plus radiotherapy in sarcomas: Improving cancer control with radiosensitizing agents. Cancer Control 15:38–46, 2008.

Bacci G, Ferrari C, Longhi A, et al: Second malignant neoplasm in patients with osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy. J Pediatr Hematol Oncol 28:774–780, 2006.

(MORE: Soft-Tissue Sarcomas)

Beck R, Monument MJ, Watkins WS, et al: EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations. Cancer Genet 205:304–312, 2012.

Blaney S, Berg SL, Pratt C, et al: A phase I study of irinotecan(Drug information on irinotecan) in pediatric patients: A Pediatric Oncology Group study. Clin Cancer Res 7:32–37, 2001.

Bölling T, Schuck A, Paulussen M, et al: Whole lung irradiation in patients with exclusively pulmonary metastases of Ewing tumors. Toxicity analysis and treatment results of the EICESS-92 trial. Strahlenther Onkol 184:193–197, 2008.

Calvert GT, Randall RL, Jones KB, et al: At-risk populations for osteosarcoma: The syndromes and beyond. Sarcoma 2012;2012:152382. 2012 Mar 12. [Epub]

Chow WA: Update on chondrosarcomas. Curr Opin Oncol 19:371–376, 2007.

DeLaney TF, Park L, Goldberg SI, et al: Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 61:492–498, 2005.

DuBois SG, Krailo MD, Gebhardt MC, et al: Evaluation of local control strategies in patients with localized Ewing sarcoma of bone: A report from the Children's Oncology Group. J Clin Oncol 30(suppl):abstract 9537, 2012.

Ferrari S, Smeland S, Mercuri M, et al: Neoadjuvant chemotherapy with high-dose ifosfamide(Drug information on ifosfamide), high-dose methotrexate(Drug information on methotrexate), cisplatin(Drug information on cisplatin), and doxorubicin(Drug information on doxorubicin) for patients with localized osteosarcoma of the extremity: A joint study by the Italian and Scandinavian Sarcoma Groups. J Clin Oncol 23:8845–8852, 2005.

Frink SJ, Rutledge J, Lewis VO, et al: Favorable long-term results of prosthetic arthroplasty of the knee for distal femur neoplasms. Clin Orthop Relat Res 438:65–70, 2005.

Fuchs B, Kotajarvi BR, Kaufman KR, et al: Functional outcome of patients with rotationplasty about the knee. Clin Orthop Relat Res (415):52–58, 2003.

Granowetter L, Womer R, Devidas M, et al: Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: A Children's Oncology Group Study. J Clin Oncol 27:2536–2541, 2009.

Grier HE, Krailo MD, Tarbell NJ, et al: Addition of ifosfamide and etoposide(Drug information on etoposide) to standard chemotherapy in Ewing's sarcoma/primitive neuroectodermal tumor of bone. N Engl J Med 384:694–701, 2003.

Grimer RJ, Carter SR, Tillman RM, et al: Chondrosarcoma of bone: An assessment of outcome. J Bone Joint Surg Am 82:1203–1204, 2000.

Indelicato DJ, Keole SR, Shahlaee AH, et al: Long-term clinical and functional outcomes after treatment for localized Ewing's tumor of the lower extremity. Int J Radiat Oncol Biol Phys 70:501–509, 2008.

Israelsen RB, Illum BE, Crabtree S, et al: Extremity sarcoma surgery in younger children: Ten years of patients ten years and under. Iowa Orthop J 31:145–153, 2011.

Jeys LM, Kulkarni A, Grimer RJ, et al: Endoprosthetic reconstruction for the treatment of musculoskeletal tumors of the appendicular skeleton and pelvis. J Bone Joint Surg Am 90:1265–1271, 2008.

Ji J, Hemminki K: Familial risk for histology-specific bone cancers: An updated study in Sweden. Eur J Cancer 42:2343–2349, 2006.

Jones KB, Salah Z, Del Mare S, et al: miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res 72:1865–1877, 2012.

Kager L, Zoubek A, Pötschger U, et al: Primary metastatic osteosarcoma: Presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol 21:2011–2018, 2003.

Koontz BF, Clough RW, Halperin EC: Palliative radiation therapy for metastatic Ewing sarcoma. Cancer 106:1790–1793, 2006.

La TH, Meyers PA, Wexler LH, et al: Radiation therapy for Ewing's sarcoma: Results from Memorial Sloan-Kettering in the modern era. Int J Radiat Oncol Biol Phys 64:544–550, 2006.

Ladanyi M: EWS-FLI1 and Ewing's sarcoma: Recent molecular data and new insights. Cancer Biol Ther 1:330–336, 2002.

Lewis IJ, Nooij MA, Whelan J, et al: Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst 99:112–128, 2007.

Loeb D, Garret-Mayer E, Hobbs R, et al: Dose-finding study of 153Sm-EDTMP in patients with poor-prognosis osteosarcoma. Cancer 115:2514–2522, 2009.

Longhi A, Ferrari S, Bacci G, et al: Long-term follow-up of patients with doxorubicin-induced cardiac toxicity after chemotherapy for osteosarcoma. Anticancer Drugs 18:737–744, 2007.

Machak GN, Tkachev SI, Solovyev YN, et al: Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities. Mayo Clin Proc 78:147–155, 2003.

Martins-Green M, Boudreau N, Bissell MJ: Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res 54:4334–4341, 1994.

Meyers PA, Schwartz CL, Krailo M, et al: Osteosarcoma: A randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol 23:2004–2011, 2005.

Miser JS, Goldsby RE, Chen Z, et al: Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: Evaluation of increasing the dose intensity of chemotherapy—a report from the Children's Oncology Group. Pediatr Blood Cancer 49:894–900, 2007.

Rodriguez-Galindo C, Navid F, Liu T, et al: Prognostic factors for local and distant control in Ewing sarcoma family of tumors. Ann Oncol 19:814–820, 2008.

Schuck A, Ahrens S, Paulussen M, et al: Local therapy in localized Ewing tumors: Results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 55:168–177, 2003.

Tsukushi S, Nishida Y, Takahashi M, et al: Clavicula pro humero reconstruction after wide resection of the proximal humerus. Clin Orthop Relat Res 447:132–137, 2006.

Wagner LM, McAllister N, Goldsby RE, et al: Temozolomide(Drug information on temozolomide) and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer 48:132–139, 2007.

Womer RB, West DC, Krailo MD, et al: Randomized comparison of every-two-week v. every-three-week chemotherapy in Ewing sarcoma family tumors. J Clin Oncol 26:abstract 10504, 2008.

Yock TI, Krailo M, Fryer CJ, et al: Local control in pelvic Ewing sarcoma: Analysis from INT-0091—a report from the Children's Oncology Group. J Clin Oncol 24:3838–3843, 2006.

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Cancer Management: Sarcomas

Bone Sarcomas

Soft-Tissue Sarcomas





 
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