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Home » Cancer Management: A Multidisciplinary Approach

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CANCER MANAGEMENT: ONLINE EDITION 

Hematopoietic Cell Transplantation

By Stephen J. Forman, MD1, Ryotaro Nakamura, MD2 | November 30, 2011
1Division of Surgery, Albert Einstein Medical Center
2Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center

  • TABLE OF CONTENTS
  • Types of transplantation
  • Allogenic transplantation
  • Autologous transplantation
  • Modifications of the stem cell graft
  • Collections of the graft
  • Indications for transplantation
  • Timing of transplantation
  • Phases of transplantation
  • Management of relapse
  • Second malignancy after HCT
  • Suggested reading

Suggested reading


Antin JH: Long-term care after hematopoietic-cell transplantation in adults. N Engl J Med 347:36-42, 2002.

Appelbaum FR, Forman SJ, Negrin RS, et al (eds): Hematopoietic Cell Transplantation, 4th ed. Malden, Massachusetts: Blackwell Science, 2009.

Brunstein CG, Fuchs EJ, Carter SL, et al: Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 118:282-288, 2011.

Brunstein CG, Gutman JA, Weisdorf DJ, et al: Allogeneic hematopoietic cell transplantation for hematological malignancy: Relative risks and benefits of double umbilical cord blood. Blood 116:4693-4699, 2010.

Cutler C, Kim HT, Ayanian S, et al: Prediction of veno-occlusive disease using biomarkers of endothelial injury. Biol Blood Marrow Transplant 16:1180–1185, 2010.

Deeg HJ, Sandmaier BM: Who is fit for allogeneic transplantation? Blood 116:4762-4770. 2010.

de Lima M, Giralt S: Allogeneic transplantation for the elderly patient with acute myelogenous leukemia or myelodysplastic syndrome. Semin Hematol 43:107–117, 2006.

Fröhling S, Schlenk RF, Breitruck J, et al: Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 100:4372-4380, 2002.

Fung HC, Cohen S, Rodriguez R, et al: Reduced-intensity allogeneic stem cell transplantation for patients whose prior autologous stem cell transplantation for hematologic malignancy failed. Biol Blood Marrow Transplant 9:649–656, 2003.

Geisler CH, Kolstad A, Laurell A, et al: Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: A nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 112:2687–2693, 2008.

Harousseau JL, Moreau P: Evolving role of stem cell transplantation in multiple myeloma. Clin Lymphoma Myeloma 6:89–95, 2005.

Hertzberg M, Grigg A, Gottlieb D, et al: Reduced-intensity allogeneic haemopoietic stem cell transplantation induces durable responses in patients with chronic B-lymphoproliferative disorders. Bone Marrow Transplant 37:923–928, 2006.

Ho VT, Aldridge J, Kim HT, et al: Comparison of Tacrolimus(Drug information on tacrolimus) and Sirolimus(Drug information on sirolimus) (Tac/Sir) versus Tacrolimus, Sirolimus, and mini-methotrexate (Tac/Sir/MTX) as acute graft-versus-host disease prophylaxis after reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 15:844–850, 2009.

Ito JI, Kriengkauykiat J, Dadwal SS, et al: Approaches to the early treatment of invasive fungal infection. Leuk Lymphoma 51:1623–1631, 2010.

Krishnan A, Nademanee A, Fung HC, et al: Phase II trial of transplantation regimen of yttrium-90 ibritumomab tiuxetan and high-dose chemotherapy in patients with non-Hodgkin's lymphoma. J Clin Oncol 26:90–95, 2008.

Laughlin MJ, Eapen M, Rubinstein P, et al: Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351:2265–2275, 2004.

Lavoie JC, Connors JM, Phillips GL, et al: High-dose chemotherapy and autologous stem cell transplantation for primary refractory or relapsed Hodgkin lymphoma: Long-term outcome in the first 100 patients treated in Vancouver. Blood 106:1473–1478, 2005.

Lokhorst H, Einsele H, Vesole D, et al: International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma. J Clin Oncol 28:4521-4530, 2010.

Loren AW, Chow E, Jacobsohn DA, et al: Pregnancy after hematopoietic-cell transplantation: A report from the late effects working committee of the center for international blood and marrow transplant research (CIBMTR). Biol Blood Marrow Transplant 17:157-166, 2011.

Maloney DG, Molina AJ, Sahebi F, et al: Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma. Blood 102:3447–3454, 2003.

Martin PJ, Counts GW Jr, Appelbaum FR, et al: Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol 28:1011–1016, 2010.

Michallet M, Ito JI: Approaches to the management of invasive fungal infections in hematologic malignancy and hematopoietic cell transplantation. J Clin Oncol 27:3398–3409, 2009.

Nademanee A, Forman S, Molina A, et al: A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide(Drug information on cyclophosphamide) followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma. Blood 106:2896–2902, 2005.

Oliansky DM, Czuczman M, Fisher RI, et al: The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of diffuse large b-cell lymphoma: Update of the 2001 evidence-based review. Biol Blood Marrow Transplant 17:20-47, 2011.

Paczesny S, Choi SW, Ferrara JL: Acute graft-versus-host disease: New treatment strategies. Curr Opin Hematol 16:427–436, 2009.

Paschka P, Marcucci G, Ruppert AS, et al: Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 24:3904–3911, 2006.

Richardson PG, Soiffer RJ, Antin JH, et al: Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: A multicenter, randomized, dose-finding trial. Biol Blood Marrow Transplant 16:1005–1017, 2010.

Rodriguez R, Nakamura R, Palmer JM, et al: A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens. Blood 115:1098–1105, 2010.

Snyder DS, Palmer J, Gaal K, et al: Improved outcomes using tacrolimus/sirolimus for graft-versus-host disease prophylaxis with a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplant as treatment of myelofibrosis. Biol Blood Marrow Transplant 16:281–286, 2010.

Sun CL, Francisco L, Kawashima T, et al: Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: A report from the Bone Marrow Transplant Survivor Study. Blood 116:3129-3139, 2010.

Syrjala KL, Langer SL, Abrams JR, et al: Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls. J Clin Oncol 23:6596–6606, 2005.

Tauro S, Craddock C, Peggs K, et al: Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia. J Clin Oncol 23:9387–9393, 2005.

Tuthill M, Chen F, Paston S, et al: The prevention and treatment of cytomegalovirus infection in haematopoietic stem cell transplantation. Cancer Immunol Immunother 58:1481–1488, 2009.

Wagner JE, Gluckman E: Umbilical cord blood transplantation: The first 20 years. Semin Hematol 47:3–12, 2010.

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Cancer Management: Hematologic malignancies

Hodgkin Lymphoma

Non-Hodgkin Lymphoma

Multiple Myeloma and Other Plasma Cell Dyscrasias

Acute Leukemias

Chronic Myeloid Leukemia

Chronic Lymphocytic Leukemia and Hairy-Cell Leukemia

Myelodysplastic Syndromes

Hematopoietic Cell Transplantation






 
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