IMAGES Chronic myeloid leukemia (CML): marked leucocytosis with granulocyte left shift. Source: Paulo Mourao, Wikimedia Commons
Microscopic analysis of blood smear stained with May-Grünwald/Giemsa, from a patient with Chronic Myeloid Leukemia. Source: Dr Ramon Simon-Lopez, Wikimedia Commons
VIDEOS Dr. Sonali Smith discusses the newest developments in the treatment of CML.
Dr. Jorge Cortes discusses new data on bosutinib, a new tyrosine kinase inhibitor for CML.
The FDA has granted imatinib full approval as an adjuvant treatment following surgical removal of CD117-positive gastrointestinal stromal tumors in adult patients. This comes after results from a... More »
The results of the 2-year follow-up of the dasatinib DASISION phase III trial show the continued superiority of the drug compared to imatinib. The results provide further support for treatment of... More »
Hematopoietic malignancies account for 6% to 8% of new cancers diagnosed annually. In the year 2010, an estimated 43,050 new cases of leukemia were diagnosed, and 21,840 deaths were attributable to... More »
Hematopoietic cell transplantation (HCT) is the IV infusion of hematopoietic stem and progenitor cells designed to establish marrow and immune function in patients with a variety of acquired and... More »
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of the primitive hematopoietic stem cell. More »
Myelodysplastic syndromes (MDS) are a group of hematologic malignancies of the pluripotent hematopoietic stem cells. These disorders are characterized by ineffective hematopoiesis, including... More »
Paraneoplastic pemphigus (PNP) is an autoimmune-mediated, blistering, erosive, and painful mucocutaneous disease that is diagnosed almost exclusively in patients with lymphocytic neoplasms. More »
A 63-year-old male was hospitalized following a massive hemorrhage secondary to a motor vehicle accident and subsequent infection of a surgical site. Three weeks post-admittance his WBC demonstrated a... More »
The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by producing transparent, externally fertilized embryos. Embryonic zebrafish are easily visualized and manipulated through microinjection, chemical treatment, and mutagenesis. These procedures have contributed to large-scale chemical, suppressor, and genetic screens to identify hematopoietic gen
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
News and Views. Nature Reviews Clinical Oncology 8, 693-694( December 2011) |. doi. : 10.1038/nrclinonc.2011.168. Subject Categories: Medical Oncology | Targeted therapies. ... Druker, B. J. et al. Five-year follow-up of patients receiving imatinib for
Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular machinery that causes the cell to replicate at a higher rate and results in the loss of apoptosis. Therefore, a delicate balance between the expression of various genes involved in proliferation and apoptosis decide the ultimate fate of the cell to undergo rapid proliferation (cancer) or cell death.|Hepat
After the MTD is determined, additional patients with myelodysplastic syndromes ( MDS) or acute myeloidleukemia ( with trilineage dysplasia or arising from MDS) are randomized to 1 of 2 treatment arms. ... Relapsed or refractory acute myeloidleukemia (
Acute Lymphoblastic Leukemia. Acute Myeloblastic Leukemia. ChronicMyeloidLeukemia. Procedure: Blood test. ... Patient that will be treated by an HSC graft. Initial pathology of recipient: acute lymphoblastic leukemia, acute myeloblastic leukemia,
'What They Should Really Teach in Medical School' Julie Schopps, MD , February 6, 2012 The North Carolina-based pediatrician weighs in on why she thinks the real learning doesn't take place until students are out of the classroom.
Improve EHR Systems by Rethinking Medical Billing Daniel Essin, MA, MD, February 6, 2012 Separating billing-related data from other clinical documentation and transmitting it to a billing system is not difficult …no matter how the charting is done.