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Chronic myeloid leukemia (CML): marked leucocytosis with granulocyte left shift. Source: Paulo Mourao, Wikimedia Commons


Microscopic analysis of blood smear stained with May-Grünwald/Giemsa, from a patient with Chronic Myeloid Leukemia. Source: Dr Ramon Simon-Lopez, Wikimedia Commons

VIDEOS
Dr. Sonali Smith discusses the newest developments in the treatment of CML.


Dr. Jorge Cortes discusses new data on bosutinib, a new tyrosine kinase inhibitor for CML.
 

 
NEWS
Medical News: ASH: Major Studies on Tap for 2011 Meeting - in Meeting Coverage, ASH: Hematology from MedPage Today
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Chronic Myeloid Leukemia
 
FEATURED CONTENT
February 6, 2012
FDA Grants Imatinib (Gleevec) Full Approval for Adjuvant Treatment of GIST
The FDA has granted imatinib full approval as an adjuvant treatment following surgical removal of CD117-positive gastrointestinal stromal tumors in adult patients. This comes after results from a... More »
January 17, 2012
What to Order From the Prostate Cancer Treatment Menu?
These are, indeed, exciting times for patients with metastatic prostate cancer and the clinicians who care for them. More »
January 13, 2012
Continuing Good News for Chronic Myeloid Leukemia Patients
The results of the 2-year follow-up of the dasatinib DASISION phase III trial show the continued superiority of the drug compared to imatinib. The results provide further support for treatment of... More »
December 31, 2011
Acute Leukemias
Hematopoietic malignancies account for 6% to 8% of new cancers diagnosed annually. In the year 2010, an estimated 43,050 new cases of leukemia were diagnosed, and 21,840 deaths were attributable to... More »
December 20, 2011
Fluid Complications
Malignant pleural effusion complicates the care of approximately 150,000 people in the United States each year. More »
November 30, 2011
Hematopoietic Cell Transplantation
Hematopoietic cell transplantation (HCT) is the IV infusion of hematopoietic stem and progenitor cells designed to establish marrow and immune function in patients with a variety of acquired and... More »
November 10, 2011
Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of the primitive hematopoietic stem cell. More »
November 10, 2011
Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are a group of hematologic malignancies of the pluripotent hematopoietic stem cells. These disorders are characterized by ineffective hematopoiesis, including... More »
October 12, 2011
Mucocutaneous Paraneoplastic Syndromes Associated With Hematologic Malignancies
Paraneoplastic pemphigus (PNP) is an autoimmune-mediated, blistering, erosive, and painful mucocutaneous disease that is diagnosed almost exclusively in patients with lymphocytic neoplasms. More »
August 19, 2011
63-year-old Male Hospitalized Following a Massive Hemorrhage
A 63-year-old male was hospitalized following a massive hemorrhage secondary to a motor vehicle accident and subsequent infection of a surgical site. Three weeks post-admittance his WBC demonstrated a... More »
Showing 1 - 10 of 122 results.
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JOURNAL SCAN
Oncogene - Abstract of article: STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis
www.nature.com - 1/9/12
Oncogene is one of the worlds leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes.
Genome Medicine | Full text | Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
genomemedicine.com - 12/29/11
The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by producing transparent, externally fertilized embryos. Embryonic zebrafish are easily visualized and manipulated through microinjection, chemical treatment, and mutagenesis. These procedures have contributed to large-scale chemical, suppressor, and genetic screens to identify hematopoietic gen
British Journal of Cancer - Genetic and proteomic approaches to identify cancer drug targets
www.nature.com - 12/13/11
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
Opinion: A personal note[mdash]40 years after the signing of the Cancer Act : Article : Nature Reviews Clinical Oncology
www.nature.com - 11/1/11
News and Views. Nature Reviews Clinical Oncology 8, 693-694( December 2011) |. doi. : 10.1038/nrclinonc.2011.168. Subject Categories: Medical Oncology | Targeted therapies. ... Druker, B. J. et al. Five-year follow-up of patients receiving imatinib for
Cancer Cell International | Full text | Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1
www.cancerci.com - 10/28/11
Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular machinery that causes the cell to replicate at a higher rate and results in the loss of apoptosis. Therefore, a delicate balance between the expression of various genes involved in proliferation and apoptosis decide the ultimate fate of the cell to undergo rapid proliferation (cancer) or cell death.|Hepat

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CLINICAL TRIALS
An Open-Label, Multicenter, Expanded Access Study of Oral AMN 107 in Adult Patients With Imatinib (Glivec/Gleevec_ - Resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase - Full Text View - ClinicalTrials.
www.clinicaltrials.gov -
Immunotherapy for Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Blast Phase Chronic Myelogenous Leukemia (BP CML), and Mydelodysplastic Syndrome (MDS) Relapse After Allogeneic Transplantation - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Safety and Tolerability Study of INNO-406 to Treat Chronic Myeloid Leukemia or Acute Lymphocytic Leukemia - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
A Study of Dasatinib vs. High-Dose Imatinib (600 mg) in Patients With Chronic Phase Chronic Myeloid Leukemia (CML) Who Failed to Achieve Complete Cytogenetic Response After 3-18 Months of Imatinib Therapy - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Study of XL228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemia - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
 
MEDLINE
A Phase I Trial of Alloreactive Cell Infusion Following Transplantation of Haplotype Cells in Patients With Myeloid Malignancies - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Leukemia, Myeloid, Acute. Leukemia, Lymphoid. Myelodysplastic Syndromes. Leukemia, Myelogenous, Chronic. Device: CliniMACS CD34 Reagent System. ... Leukemia, Myeloid, Acute. Leukemia, Myeloid. Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
Registration of Children With CML and Treatment With Imatinib - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Myeloid Leukemia, Chronic. Study Type:. Observational. Study Design:. ObservationalModel: Cohort. TimePerspective: Prospective. ... Leukemia. Leukemia, Myeloid. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Philadelphia Chromosome. Chronic
PXD101 and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
After the MTD is determined, additional patients with myelodysplastic syndromes ( MDS) or acute myeloid leukemia ( with trilineage dysplasia or arising from MDS) are randomized to 1 of 2 treatment arms. ... Relapsed or refractory acute myeloid leukemia (
Natural Killer Index From Hematopoietic Stem Cell Graft - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Acute Lymphoblastic Leukemia. Acute Myeloblastic Leukemia. Chronic Myeloid Leukemia. Procedure: Blood test. ... Patient that will be treated by an HSC graft. Initial pathology of recipient: acute lymphoblastic leukemia, acute myeloblastic leukemia,
Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Acute Myeloid Leukemia. Acute Lymphoblastic Leukemia. Myelodysplasia. Chronic Myeloid Leukemia. Radiation: Total Body Irradiation. ... Leukemia, Myeloid, Acute. Leukemia, Myeloid. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Myelodysplastic Syndromes

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FROM PHYSICIANS PRACTICE
'What They Should Really Teach in Medical School'
Julie Schopps, MD , February 6, 2012
The North Carolina-based pediatrician weighs in on why she thinks the real learning doesn't take place until students are out of the classroom.
Improve EHR Systems by Rethinking Medical Billing
Daniel Essin, MA, MD, February 6, 2012
Separating billing-related data from other clinical documentation and transmitting it to a billing system is not difficult …no matter how the charting is done.
Keeping Your Medical Practice’s Accounts Receivable on Track
P.J. Cloud-Moulds, February 4, 2012
Here are the minimum reports you should be running to keep an eye on your practices A/R.
Healthcare Providers Play Crucial Role in Helping Victims of Abuse
Stephen Hanson, PA-C , February 3, 2012
I would urge each and every one of you to be familiar with the warning signs of abuse, and the resources available to you all as healthcare providers.
Protecting Your Medical Practice's Data
Marisa Torrieri, February 3, 2012
Here's the scoop on how to implement a good data-backup plan at your office.
 
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