NSAIDs Reduce Colorectal Cancer Risk in High-Risk Patients

May 19, 2011

The known association between non-steroidal anti-inflammatory drugs (NSAIDs) and colorectal cancer is strengthened by studyingindividuals at high risk. Retrospective analysis of data from the NIH-AARP Diet and Health Study shows that, among those participants with a family history of colorectal cancer, taking an NSAID every day significantly reduced their own risk of developing the cancer. The association differed by medication type and malignancy: Daily aspirin(Drug information on aspirin) significantly reduced the risk of rectal cancer, and taking a non-aspirin NSAID every day lowered the risk of colon cancer.

RESULT: Non-Steroidal Anti-Inflammatory Drugs and Colorectal Cancer Risk in a Large, Prospective Cohort
American Journal of Gastroenterology | Apr 15, 2011 (Free abstract. Full text $32)

The verdict is still out on whether daily low-dose aspirin reduces the risk for everyone, because large US and European studies disagree on the association. In a case-control study looking at 15 years of data from 574 general practices in the UK, researchers at the Nottingham Digestive Disease Center found a gradual reduction in risk with longer use of low-dose aspirin, which was only evident after 7 years. Adding calcium may increase the effect, they suggest.

RESULT: Is low-dose aspirin use associated with a reduced risk of colorectal cancer? A QResearch primary care database analysis
Gut | Apr 1, 2011 (Free abstract. Full text $30)

Among cases from the Seattle Colon Cancer Family Registry, long-term regular use of NSAIDS before colorectal cancer diagnosis was associated with about a 20% increase in survival compared with patients who never took NSAIDs. The association was strongest with proximal disease and longer use of NSAIDs.

RESULT: Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer
Gut | Apr 1, 2011 (Free abstract. Full text $30)

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NSAIDs Reduce Colorectal Cancer Risk in High-Risk Patients

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