RESEARCH REPORT Leah Lawrence Women diagnosed with endometrial cancer at age 50 or younger had a fourfold increased risk for a subsequent colorectal cancer diagnosis, according to a historical cohort study published recently in the Journal of Clinical Oncology.
RESEARCH REPORT Leah Lawrence Adding the VEGF inhibitor axitinib to first-line treatment of FOLFOX-6 for metastatic colorectal cancer failed to improve progression-free and overall survival.
RESEARCH REPORT Anna Azvolinsky Patients with stage III colon cancer who have a history of smoking are more likely to have worse outcomes, according to a large, randomized phase III trial result.
TEST YOUR IMAGE IQ Cesar Moran A 72-year-old man presents with symptoms of abdominal pain and blood in his stools. A biopsy of the colon is obtained. What is your diagnosis?
REVIEW ARTICLE Francesco Cellini, Vincenzo Valentini;ONCOLOGY Vol. 26 No. 8 The preferred integrated treatment modality for locally advanced rectal cancer is preoperative radio(chemo)therapy followed by total mesorectal excision, though certain aspects of this standard are still debated.
Despite significant advances in targeted biologic agents and their integration with cytotoxic chemotherapy regimens, the overall impact of these regimens in mCRC therapy has been relatively modest. This article reviews the main issues that must be considered from the surgical oncology and medical oncology perspectives, respectively.
• Metastatic Colorectal Cancer: A Curable Disease • Metastatic Colorectal Cancer: Potential for Cure?
Patients who have chronic constipation may be at increased risk for colorectal cancer and benign neoplasms, researchers reported at the American College of Gastroenterology 77th Annual Scientific Meeting. In addition, new colonoscopy surveillance... More »
The American College of Radiology and the Colon Cancer Alliance call on Congress to pass HR 4165, which would cover CT colonography screening under Medicare. More »
Reps. Danny Davis (D, Ill.) and Ralph Hall (R, Texas) introduced the CT Colonography Screening for Colorectal Cancer Act of 2012 on the heels of data showing CTC's effectiveness in seniors. More »
CT colonography is a better screening test than optical colonoscopy (OC), according to a new study published in the May Radiology print issue. Using meta-analysis of studies done over a 15 year period, authors found that the sensitivity of CT... More »
Despite the increasing popularity of blood testing for colorectal cancer, radiologists don’t have to worry CT colonography will be replaced just yet, according to experts. More »
Statins are associated with a slight reduction in the risk of colorectal cancer, according to the results of a recent meta-analysis presented at the 2010 American College of Gastroenterology meeting. Investigators at the University of Michigan at Ann... More »
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including
Although experimental studies have shown lipoprotein(a) antiangiogenic and antitumoral effects, the association of lipoprotein(a) levels with cancer in population studies remains elusive and poorly documented. The aim of this study was to analy
Decision making for adjuvant chemotherapy in stage III colon cancer is based on the TNM system. It is well known that prognosis worsens with higher pN classification, and several recent studies propose superiority of the lymph node ratio (ln ratio) to the TNM system. Therefore, we compared the prognosis of ln ratio to TNM system in our stage III colon cancer patients.|Decision making for adjuvant chemotherapy in stage III colon cancer is based on the TNM system. It is well known that prognosis worsens with
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50000 individuals. By - Prof Stein Emil Vollset MD, Dr Ro...
The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is mostly known for its importance in the maintenance of calcium and phosphate homeostasis. However, next to its classical effects on bone, kidney and intestine, 1,25(OH)2D3 also exerts antineoplastic effects on various types of cancer. The use of 1,25(OH)2D3 itself as treatment against neoplasia is hampered by its calcemic side effects. Therefo
Robotic approaches in all surgical realms have seen tremendous growth over the previous few years. Taking advantage of 3-dimensional visualization, improved articulation, and the opportunity for an enhanced ability to suture/operate in the deep pelvis all provide theoretical and real advantages in colorectal surgery. This article reviews the potential advantages and disadvantages, current indications, future directions, and lessons learned for robotic approaches in colorectal surgery.
Locally recurrent rectal cancer relapses in the pelvis in up to 60 per cent of patients following resection. This study assessed the surgical and oncological outcomes of patients who underwent surgery for re-recurrent rectal cancer.|Patients who underwent second-time resection of locally recurrent rectal cancer between 2001 and 2010 were eligible for inclusion. Data were collected on demographics, presentation of disease, preoperative staging imaging, adjuvant therapy, operative detail, histopathology and follow-up status (clinical and imaging) for the primary tumour, and first and second recurrences.|Thirty patients (of 56 discussed at the multidisciplinary meeting) underwent resection of re-recurrent rectal cancer. Postoperative morbidity occurred in nine patients but none died within 30 days. Negative resection margins (R0) were achieved in ten patients, microscopic margin positivity (R1) was evident in 15 and macroscopic involvement (R2) was found in five. Although no patient had
The International Cancer Benchmarking Partnership is investigating cancer survival differences between six high-income nations using population-based cancer registry data. Differences in overall survival are often explained by differences in the stage at diagnosis and stage-specific survival. Comparing stage at diagnosis using cancer registry data is challenging because of different regional practices in defining stage, despite the existence of international staging classifications such as TNM. This paper describes how stage data may be reconciled for international analysis. Population-based cancer registry data were collected for 2.4 million adults diagnosed with colorectal, lung, breast (women) or ovarian cancer during 1995-2007 in Australia, Canada, Denmark, Norway, Sweden and the United Kingdom. The stage data received were coded to a variety of international systems, including the TNM classification, Dukes' for colorectalcancer, FIGO for ovarian cancer, and to national "localised
Colorectal disease in pediatric patients includes a spectrum of diseases, many of which have a significant impact on quality of life and warrant long-term follow-up and treatment into adulthood. Although many diseases, such as inflammatory bowel disease and colon cancer, are managed similar to adults, other disease processes are more common to pediatric patients and are the focus of this article.
Antiangiogenesis is an efficient therapy for eliminating colon cancers, but because of recurrence it remains only palliative. We hypothesized that certain populations of tumor cells resist antiangiogenesis-induced apoptosis and explored the underlying mechanism. We demonstrated that the CD133(+) population of cells in colon cancer is resistant to anti-angiogenesis therapy. Additionally, we identified an anti-apoptotic signaling pathway responsible for this resistance involving PP2A, p38MAPK, MAPKAPK2, and Hsp27. Thus, this pathway may offer a new avenue to develop target therapy for colorectalcancer.
In this interview we discuss the advances in treatment for colorectal cancer, as well as ongoing developments to find new and better therapies to treat this type of cancer.
Key Differences between FQHCs and RHCs Chastity Werner, RHIT, June 13, 2013 FQHCs and RHCs take up a unique niche among physician practices. And that affects compensation and billing.
Improving Care Coordination in Your Practice Susanne Madden, June 12, 2013 Practices are feverishly working to control the rising costs of healthcare - effective care coordination can help.
Refunding Overpayments: Two Options for Medical Practices Ericka L. Adler, June 12, 2013 Medicare and Medicaid providers must return overpayments once identified. Here are two different refund approaches for practices to consider when necessary.
iPad Alternatives for Mobile Physicians Marisa Torrieri, June 11, 2013 As more physicians are seeing the merits of media tablets, the market is expanding, too.
The preferred integrated treatment modality for locally advanced rectal cancer is preoperative radio(chemo)therapy followed by total mesorectal excision, though certain aspects of this standard are still debated.
In this article, we use a case-based approach to focus on the hereditary aspects of the most common GI cancers, including pancreatic, gastric, and colon cancer.
Despite significant advances in targeted biologic agents and their integration with cytotoxic chemotherapy regimens, the overall impact of these regimens in mCRC therapy has been relatively modest. This article reviews the main issues that must be considered from the surgical oncology and medical oncology perspectives, respectively.
Treatment for patients with locally advanced, resectable rectal cancer has clearly evolved, with significant refinements in preoperative assessment, surgical technique, and use of preoperative CMT. 
Colorectal cancer is the third leading cause of cancer-related deaths in... 
A 47-year-old male with complaints of chronic abdominal pain and episodes of flushing presents for evaluation. What is your diagnosis?
In this interview we discuss the advances in treatment for colorectal cancer, as well as ongoing developments to find new and better therapies to treat this type of cancer.
