American Society of Hematology
Dr. Steven Rosen
In recent years, experts in the field of hematologic malignancies have seen a panoply of drugs gain a place in our treatment armamentarium. Some of the breakthroughs include the approval of histone deacetylase (HDAC) inhibitors in chronic lymphocytic leukemia (CLL) and peripheral lymphoma; the application of novel alkylating agents, such as bendamustine (Treanda), in CLL and various lymphomas; and the incorporation of dasatinib (Sprycel) for treating chronic myeloid leukemia patients who prove resistant to imatinib (Gleevec).
We now find ourselves focusing on how to design the most effective strategies, including drug sequencing, to maximize benefit for our patients. The 2010 American Society of Hematology meeting (ASH) offers the chance to delve deeper into the best ways to maximize treatment for our patients. Join Oncology NEWS International for onsite reports from ASH 2010 as we bring you a bird’s eye view of the research, trials, scientific advances, and controversies that are changing the way hematologic malignancies are managed and treated.
Check back here daily during the meeting and watch your inbox for our exciting reports from the ASH 2010 meeting.
Ofatumumab generates high response rates in refractory CLL
December 10, 2010
Ofatumumab (Arzerra) demonstrated clinical benefit was superior to historic outcomes with salvage therapies in this setting, according to lead investigator William G. Wierda, MD, PhD. After about 26 months of median follow-up, progression-free survival and overall survival improved in fludarabine-refractory chronic lymphocytic leukemia and in fludarabine-refractory CLL with bulky lymph nodes.
Novel HDAC inhibitor offers hope in heavily pretreated HL patients
December 9, 2010
Phase II study results are encouraging because this patient population generally sees a median of five prior lines of therapy including transplants, explained Jeffrey M. Besterman, MD, PhD, executive vice president and chief scientific officer for MethylGene, the developer of mocetinostat (MGCD0103).
Nilotinib Exerts Positive Effect in Early Chronic Phase Ph+ CML
December 7, 2010
At a median follow-up of 36 months, multiple survival rates were nearly perfect at 99%. The leader of the Italian study called the low number of treatment failures reassuring news as to the durability of nilotinib response at three years post-therapy
Deeper Molecular Responses Seen with Dasatinib in New Chronic Myeloid Leukemia
December 7, 2010
The median reductions in Bcr-Abl transcripts at one year were greater with dasatinib (Sprycel) than with imatinib (Gleevec), according to the results of an intergroup phase II trial. A better molecular response should eventually correlate with better outcomes, making dasatinib a serious contender for upfront therapy in CML.
Nilotinib Continues to Surpass Imatinib in Newly Diagnosed CML
December 6, 2010
The 24-month follow-up data from the ENESTnd trial showed that patients treated with nilotinib (Tasigna) had significantly better response rates and significantly lower rates of progression to accelerated phase or blast crisis when on treatment.
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