Oncology NEWS International. Vol. 17 No. 6

Radioactive microspheres benefit liver met pts

June 1, 2008

CHICAGO—Median overall survival was 13 months among 52 patients who received radioactive microspheres (SIR-Spheres) for colorectal cancer liver metastases after chemotherapy failure. The phase II Italian SITILO study was reported at ASCO 2008 (abstract 4078).

Clinical benefit was seen in 48% (1 CR, 11 PR, 12 SD). In two patients, liver tumors shrank enough to allow potentially curative surgery to be planned. Among the 24 responders, median survival was 16 months vs 8 months for nonresponders (P = .0006); 40% of responders were alive at 2 years vs none of the nonresponders.

“At a minimum, physicians should consider SIR-Spheres for patients who have liver-only or liver-dominant disease and are failing chemotherapy,” said Prof. Maurizio Cosimelli, of the Regina Elena National Cancer Institute, Rome.

by steve murrah | July 01, 2010 11:59 PM EDT

Sir Spheres uses Y90 radiation so if you have NET carcinoid tumors, one should consider PRRT therapy either Y90 or Lu177. The activity is the same and safer profile due to the ammino acid kidney protection. Of course this has to be Net carcinoid tumors with receptor positive tumors!

PRRT......cancer stops here!

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Radioactive microspheres benefit liver met pts

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