Quon and Harrison have performed a considerable service to patients with head and neck cancers by reminding the oncology community that a state-of-the-art treatment team must include state-of-the-art brachytherapy.
A fundamental adage in radiotherapy is "If you don’t hit it, you can’t cure it." Modern tools of external-beam radiotherapy, such as intensity-modulated radiation therapy, allow us to tailor radiation dose distributions (at least on the computer screen) to conform almost as tightly to the shape of the cancer as brachytherapy. In the head and neck region, however, ensuring that radiation always hits its target is not easy: Accurately repositioning and immobilizing inherently mobile structures such as the tongue, the mandible, and the cervical spine—day after day, week after week—can be quite difficult.
Advantages of Brachytherapy
With brachytherapy, one has the confidence that radiation is always hitting its target because the source of irradiation is located within the target, or right on it, rather than several feet away. Furthermore, the duration of the treatment, instead of weeks and months, is measured in days (and now, with high-dose-rate brachytherapy, in minutes). Brachytherapy is, therefore, quite appropriately described as the ultimate conformal radiotherapy and belongs in the armamentarium of physicians dealing with patients suffering from head and neck cancers.
Among the frustrations of being a head and neck brachytherapist is seeing patients after local recurrence and knowing that, if brachytherapy had been employed as part of the original planned treatment, the outcome would probably have been better. I shall, therefore, take this opportunity to amplify three of the issues discussed by Quon and Harrison in their comprehensive review, namely, (1) the role of brachytherapy in nasopharyngeal carcinoma, (2) the role of brachytherapy in the postoperative patient, and (3) the role of high-dose-rate brachytherapy.
Brachytherapy in Nasopharyngeal Carcinoma
Adequate external-beam irradiation to the nasopharynx and the retropharyngeal lymph nodes is constrained, even in the modern era, by the proximity of these sites to critical structures such as the brainstem, the optic chiasm, and the spinal cord. In the recent Intergroup study 0099, no brachytherapy was allowed, and as a result, one in three patients (23/69) treated by radiotherapy suffered local recurrence.[1] This was in striking contrast to several reports from the United States,[2-4] Europe,[5] and Asia,[6,7] suggesting that adding a planned brachytherapy boost to external irradiation led to local recurrences in fewer than 1 in 10 patients, and was quite safe.
A 70-year-old man with a history of localized prostate cancer treated with whole-pelvis radiation therapy with a boost to the prostate, in conjunction with androgen deprivation therapy 7 years prior, presented with lower back pain. A bone scan revealed an area of activity in the sacrum. What is the most likely diagnosis?
