SGO: Adjuvant Chemoradiation Shows Benefit in Advanced Endometrial Cancer

Michael Smith
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco

Explain to interested patients that traditional adjuvant therapy options for advanced endometrial cancer include chemotherapy, radiation, and the combination. New treatments include hormonal therapy.
Note that this long retrospective study suggests that for some women, the combination of chemotherapy and radiation is better then either alone in terms of overall survival and progression-free survival.
This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.

SAN DIEGO, March 7 -- Adjuvant chemoradiation may benefit some women with advanced endometrial cancer, researchers said here.

In a retrospective study, the adjuvant chemoradiation significantly improved overall survival in all patients, compared with chemotherapy (P=0.05) or radiation alone (P=0.014), according to Angeles Alvarez Secord, M.D., of Duke Medical Center in Durham, N.C.

The combination did not significantly improve progression-free survival over chemotherapy alone, but gave a slight improvement over radiation alone (P=0.043), Dr. Secord told a plenary session of the Society of Gynecologic Oncologists meeting.

However, when the analysis was restricted to patients whose tumors had been optimally debulked, Dr. Secord said, both overall and progression-free survival were markedly improved.

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