Endometrial cancer is the most
common gynecologic malignancy
affecting women in the
United States. In 1988, the International
Federation of Gynecology and
Obstetrics shifted from a clinical staging
protocol to one based on surgical
factors, making surgical staging the
accepted treatment approach to...
More »The Lynch syndrome (hereditary nonpolyposis colorectal cancer
[HNPCC]), is the most common form of hereditary colorectal cancer
(CRC), accounting for 2% to 7% of all CRC cases. The next most common
hereditary CRC syndrome is familial adenomatous polyposis (FAP),
which accounts for less than 1% of...
More »Carcinoma of the epithelial lining (endometrium) of the uterine corpus is the
most common female pelvic malignancy. The American Cancer Society (ACS)
estimates that 40,880 cases of this cancer will occur in the year 2005 in the
United States. Factors influencing its prominence are the declining...
More »BETHESDA, Maryland—Convincing evidence indicates that physical activity can significantly reduce the risk of colon and breast cancer, according to a newly released National Cancer Institute (NCI) fact sheet. Moreover, studies also suggest a link between exercise and a reduced risk of cancers of the...
More »SAN DIEGO—In a cohort of endometrial cancer patients at M.D. Anderson Cancer Center, those who had previously developed breast cancer and used tamoxifen did not have a higher incidence of high-risk histologic subtypes, compared with breast cancer patients not receiving tamoxifen, reported Brian M....
More »Four randomized prospective trials have evaluated tamoxifen for
chemoprevention of breast cancer. The National Surgical Adjuvant
Breast and Bowel Project P-1 trial reported that tamoxifen reduced the
risk of invasive breast cancer by 49%. Two smaller European trials, the
Royal Marsden Hospital...
More »Published literature indicates that the selective estrogen-receptor
modulators (SERMs) tamoxifen and raloxifene (Evista) have favorable
effects on bone density, lipid profiles, and the incidence of second
breast cancers, and unfavorable effects on the incidence of venous
thrombosis and hot flushes....
More »Over the past few decades, we have gained a better understanding of the risk factors associated with the recurrence of endometrial cancer. Adjuvant postoperative radiotherapy in an intermediate-risk group of
More »In their excellent summary of randomized trials examining the management of cancers of the uterus and ovary, Kim and coauthors highlight a significant and worrisome difference that has developed between the two gynecologic malignancies over the past decade, with regard to the direction of clinical...
More »CHICAGO—Adding paclitaxel (Taxol) and G-CSF support to the standard regimen of doxorubicin and cisplatin (Platinol) improved response rates and increased survival by about 3 months for patients with advanced or recurrent endometrial cancer in a randomized controlled phase III trial conducted by the...
More »
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