Genitourinary Cancers

This article will present current information about alpha-pharmaceuticals, a new class of targeted cancer therapy for the treatment of patients with CRPC and bone metastases. It will review preclinical and clinical studies of the experimental radiopharmaceutical radium-223 chloride (Alpharadin).
• Radium-223: Down to the Bone, and Less Is More
• An Alpha Edge?

This article will review the recent advances that form the current framework of therapy for RCC, as well as summarize key areas of progress and innovation in the evolving treatment paradigms for this disease.
• Renal Cancer Therapeutics: Now What?
• Metastatic RCC: Moving Towards a Chronic Disease

We have entered a period of accelerated drug development and optimism in the care of advanced prostate cancer. The treatment paradigm for these patients is rapidly evolving, with future study needed to define the optimal sequencing and potential combinations of these new agents.
• Sequencing of Therapies in Advanced Prostate Cancer
• What to Order From the Prostate Cancer Treatment Menu?

Muscle-invasive bladder cancer is an aggressive and potentially lethal disease. Integration of multimodal therapies, improved surgical techniques, and utilization of targeted agents has tremendously improved outcomes.
• Challenges in the Modern Treatment of Muscle-Invasive Bladder Cancer
• Bladder Cancer Treatment: Optimize, Don't Compromise

This review will examine agents with potential activity in the palliation and treatment of skeletal metastases of PCa, and will weigh the clinical-outcomes evidence for and against their broad use.
• Managing CRPC: Improving Symptoms, Survival, or Both?
• Are We Trumping Bone Disease in Prostate Cancer?

A 3-year-old child was brought to the physician’s office after the mother felt a mass in the abdominal area. Imaging revealed the presence of a mass that appeared to be in the right kidney. Surgical resection of the tumor was performed.

A 30-year-old man presented with pain and testicular swelling of his right testicle. The patient has not experienced any trauma, and states that otherwise he feels in good health.

A 28-year-old, slightly obese Caucasian woman presented with a long-standing history of intermittently painful “bumps” on both shoulders and her upper back. Review of systems disclosed regular but very heavy menstrual periods, often lasting for 7 to 9 days, and chronic constipation.

A 60-year-old woman developed metastatic renal cell carcinoma and was given oral sorafenib. Three weeks after commencing treatment, the patient became febrile without signs of localized infection and rapidly developed a nonpruritic, slightly tender cutaneous eruption.