Genitourinary Cancers

Our aims in this article are to describe the various imaging sequences that comprise the multiparametric MRI exam, as well as to review current literature on the strengths/weaknesses of these sequences; to delineate strategies for standardizing interpretation and reporting of MRI results; and to expound on the role of prostate MRI in clinical practice.
• The State of Prostate MRI in 2013: Into the Breach
• Multiparametric MRI: Standardizations Needed

This review focuses on targeted therapies related to pathways of interest for the treatment of advanced urothelial carcinoma, describing the evidence to support further investigation of these approaches.
• "Missing the Target" in Urothelial Cancer
• Advanced Urothelial Carcinoma: Moving the Field Forward

In this review we focus on the recent evolution of the concept of focal therapy and the potential applications of this management approach within an array of options currently available for patients with localized prostate cancer.
• Focal Therapy: A New Active Surveillance Tool?
• Focal Therapy of Prostate Cancer—The Challenge

This review summarizes recent findings in clinical prostate cancer research reported at the 2012 Annual Scientific Meeting of the American Society of Clinical Oncology (ASCO) and addresses their relevance to clinical practice.
• Prostate Cancer 2012: Where Do We Stand and Where Are We Heading?

We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin—spurred by the identification of c-Kit–activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec).
• Improving Harmonious Precision
• Targeted Therapy for Cancer: Asking the Right Questions

A 70-year-old man with a history of localized prostate cancer treated with whole-pelvis radiation therapy with a boost to the prostate, in conjunction with androgen deprivation therapy 7 years prior, presented with lower back pain. A bone scan revealed an area of activity in the sacrum. What is the most likely diagnosis?

A 28-year-old man presents with testicular pain of several weeks duration. Physical examination discloses the presence of a right testicular mass. Orchiectomy is performed. What is your Diagnosis?

A 63-year-old man presents with symptoms of blood in the urine that has lasted for several days. Cystoscopic examination reveals the presence of a small tumor mass in the trigone of the bladder. Surgical resection is performed.

An asymptomatic, 57-year-old man underwent a prostatic biopsy.